Table of Contents

Overview

This gene encodes the H2A protein, one of the core proteins comprising nucleosomes. Although relatively common in DLBCL, little is known about the function of these mutations.

Relevance tier by entity

Entity Tier Description
BL 3 Mutations are unlikely to be relevant to BL
DLBCL 1 High-confidence DLBCL gene
MZL 2 Role of HIST1H2BK mutations in MZL requires confirmation

Warnings

The variants reported in this gene in BL failed QC

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 56 0.0514 [0.0383,0.0645]
DLBCL GAMBL with Reddy 2,088 98 0.0469 [0.0379,0.056]
DLBCL BC 231 12 0.0519 [0.0233,0.0806]
DLBCL Dana-Farber 303 16 0.0528 [0.0276,0.078]
DLBCL NCI 470 25 0.0532 [0.0329,0.0735]
DLBCL Reddy 999 42 0.0420 [0.0296,0.0545]
DLBCL DLBCL_ICGC 85 3 0.0353 [0,0.0745]

BL

pathology Collection N mutated Incidence CI
BL GAMBL without Panea 309 14 0.0267 [0.0089,0.0445]
BL GAMBL without ICGC/Zhou 320 22 0.0665 [0.0393,0.0938]
BL GAMBL with Panea 410 23 0.0325 [0.0156,0.0495]
BL BLGSP 219 13 0.0594 [0.0281,0.0907]
BL Zhou/ICGC 90 1 0.0111 [0,0.0328]
BL Panea 101 9 0.0891 [0.0335,0.1447]

FL

pathology Collection N mutated Incidence CI
FL GAMBL without Crouch 642 13 0.0202 [0.0094,0.0311]
FL GAMBL with Crouch 1,189 25 0.0210 [0.0129,0.0292]
FL BC 379 7 0.0185 [0.0049,0.032]
FL Kalmbach 164 4 0.0244 [8e-04,0.048]
FL Crouch 547 12 0.0219 [0.0097,0.0342]
FL FL_ICGC 99 2 0.0202 [0,0.0479]

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 4.4489 0.0000 0.8064
FL 2.2017 0.0000 1.0000
DLBCL 0.9241 2.3319 0.0724

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History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2012-08-27 : Rossi : MZL 2013-01-01 : Zhang : DLBCL 2018-05-01 : Chapuy : DLBCL 2019-09-26 : Panea : BL

References

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Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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