HIST1H2BM
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| FL | GAMBL genomes | 0.69 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 2.367 | 54.179 |
| DLBCL | No | No | 1.312 | 0.000 |
| FL | No | No | 1.980 | 0.000 |
[!NOTE] First described in FL in 2023 by Russler-Germain DA
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
##
HIST1H2BM Expression 
## References 1.
Krysiak K, Gomez F, White BS, Matlock M, Miller CA, Trani L, Fronick CC,
Fulton RS, Kreisel F, Cashen AF, Carson KR, Berrien-Elliott MM, Bartlett
NL, Griffith M, Griffith OL, Fehniger TA. Recurrent somatic mutations
affecting B-cell receptor signaling pathway genes in follicular
lymphoma. Blood. 2017 Jan 26;129(4):473–483. PMCID: PMC5270390
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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