Table of Contents

Overview

The relevance of HIST1H3B mutations in DLBCL remains unclear. Selective pressure analysis did not identify this gene as significantly enriched for either missense or truncating mutations, indicating that many of these mutations may represent passengers.

Relevance tier by entity

Entity Tier Description
DLBCL 1 High-confidence DLBCL gene
PMBL 2 Role of HIST1H3B mutations in PMBL requires confirmation

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 22 0.0202 [0.0118,0.0286]
DLBCL GAMBL with Reddy 2,088 42 0.0201 [0.0141,0.0261]
DLBCL BC 231 2 0.0087 [0,0.0206]
DLBCL Dana-Farber 303 8 0.0264 [0.0083,0.0445]
DLBCL NCI 470 8 0.0170 [0.0053,0.0287]
DLBCL Reddy 999 20 0.0200 [0.0113,0.0287]
DLBCL DLBCL_ICGC 85 4 0.0471 [0.002,0.0921]

BL

pathology Collection N mutated Incidence CI
BL GAMBL without Panea 309 7 0.0227 [0.0061,0.0392]
BL GAMBL without ICGC/Zhou 320 8 0.0246 [0.0077,0.0416]
BL GAMBL with Panea 410 10 0.0241 [0.0092,0.0389]
BL BLGSP 219 5 0.0228 [0.003,0.0426]
BL Zhou/ICGC 90 2 0.0222 [0,0.0527]
BL Panea 101 3 0.0297 [0,0.0628]

FL

pathology Collection N mutated Incidence CI
FL GAMBL without Crouch 642 7 0.0109 [0.0029,0.0189]
FL GAMBL with Crouch 1,189 17 0.0143 [0.0075,0.021]
FL BC 379 3 0.0079 [0,0.0168]
FL Kalmbach 164 1 0.0061 [0,0.018]
FL Crouch 547 10 0.0183 [0.0071,0.0295]
FL FL_ICGC 99 3 0.0303 [0,0.0641]

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 9.0187 0.000 1.0000
FL 1.8444 0.000 1.0000
DLBCL 0.8530 1.059 0.7937

HIST1H3B Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr6 26032045 C>T D82N
chr6 26032029 C>G S87T
chr6 26032029 C>T S87N
chr6 26032028 G>C S87R
chr6 26032021 C>T V90M
chr6 26032017 A>G M91T

Visualizations

Protein

View coding variants in ProteinPaint hg19 or hg38

Genome

View all variants in GenomePaint hg19 or hg38

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2013-01-01 : Zhang : DLBCL 2015-02-12 : Reichel : PMBL

References

1.
Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, Cruz-Gordillo P, Knoechel B, Asmann YW, Slager SL, Novak AJ, Dogan A, Ansell SM, Link BK, Zou L, Gould J, Saksena G, Stransky N, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Hernández-Lemus E, Schwarz-Cruz y Celis A, Imaz-Rosshandler I, Ojesina AI, Jung J, Pedamallu CS, Lander ES, Habermann TM, Cerhan JR, Shipp MA, Getz G, Golub TR. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3879–3884. PMCID: PMC3309757
2.
Reichel J, Chadburn A, Rubinstein PG, Giulino-Roth L, Tam W, Liu Y, Gaiolla R, Eng K, Brody J, Inghirami G, Carlo-Stella C, Santoro A, Rahal D, Totonchy J, Elemento O, Cesarman E, Roshal M. Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells. Blood. 2015 Feb 12;125(7):1061–1072.

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

Disclaimer

The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

Share — copy and redistribute the material in any medium or format for any purpose, even commercially.

Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.