HIST1H3I
History
| Entity | Tier | Description |
|---|---|---|
| 2 | relevance in BL not firmly established | |
| 2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 0.46 |
| BL | Thomas cohort | 0.00 |
| BL | Panea cohort | 2.00 |
| FL | GAMBL genomes | 1.15 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.000 | 0 |
| DLBCL | No | No | 5.397 | 0 |
| FL | No | No | 0.838 | 0 |
[!NOTE] First described in BL in 2019 by Panea RI. First described in FL in 2023 by Russler-Germain DA
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
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HIST1H3I Expression
## References 1. Krysiak K,
Gomez F, White BS, Matlock M, Miller CA, Trani L, Fronick CC, Fulton RS,
Kreisel F, Cashen AF, Carson KR, Berrien-Elliott MM, Bartlett NL,
Griffith M, Griffith OL, Fehniger TA. Recurrent somatic mutations
affecting B-cell receptor signaling pathway genes in follicular
lymphoma. Blood. 2017 Jan 26;129(4):473–483. PMCID: PMC5270390 2. Panea
R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J,
Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major
M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G,
Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G,
Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D,
Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S,
Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt
lymphoma subtypes. Blood. 2019;


