HIST1H4J
History
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timeline
title Publication timing
2019-09-05 : Mottok : PMBL
2019-09-26 : Panea : BL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in PMBL/cHL/GZL not firmly established1 |
 |
2 | relevance in BL not firmly established2 |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 0.46 |
| BL | Thomas cohort | 0.40 |
| BL | Panea cohort | NA |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.955 | 0 |
| DLBCL | No | No | 1.504 | 0 |
| FL | No | No | 0.000 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
Representative Mutations
BL2
Rating ★ ★
★ ☆ ☆
References
1.
Mottok A, Hung SS, Chavez EA, Woolcock B,
Telenius A, Chong LC, Meissner B, Nakamura H, Rushton C, Viganò E,
Sarkozy C, Gascoyne RD, Connors JM, Ben-Neriah S, Mungall A, Marra MA,
Siebert R, Scott DW, Savage KJ, Steidl C. Integrative genomic
analysis identifies key pathogenic mechanisms in primary mediastinal
large B-cell lymphoma. Blood. 2019 Sep
5;134(10):802–813.
2.
Panea R, Love C, Shingleton JR, Reddy A, Bailey
J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N,
Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles
R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung
R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop
A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S,
Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome
landscape of Burkitt lymphoma subtypes. Blood. 2019;
