HLA-DMB

Overview

HLA-DMB, along with HLA-DMA, plays a critical role in the proper functioning of HLA class II molecules. These genes are essential for the loading of antigenic peptides onto HLA class II molecules, facilitating the presentation of these peptides to CD4+ T cells. Mutations in this gene were first described in DLBCL by Hübschmann et al.¹

Relevance tier by entity

Entity	Tier	Description
	1	High-confidence DLBCL gene

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

Entity	Collection	N	mutated	Incidence	95% CI
DLBCL	GAMBL without Reddy	1,089	43	0.0395	[0.0279,0.0511]
DLBCL	GAMBL with Reddy	2,088	43	0.0206	[0.0145,0.0267]
DLBCL	BC	231	9	0.0390	[0.014,0.0639]
DLBCL	Dana-Farber	303	6	0.0198	[0.0041,0.0355]
DLBCL	NCI	470	24	0.0511	[0.0312,0.071]
DLBCL	Reddy	999	0	0.0001	[0,7e-04]
DLBCL	DLBCL_ICGC	85	4	0.0471	[0.002,0.0921]

Mutation pattern and selective pressure estimates

Entity	Missense dN/dS	Nonsense dN/dS	Q value
BL	0.0000	0.0000	1
FL	39.1286	192.8799	0
DLBCL	4.3468	19.7448	0

Visualizations

Protein

View coding variants in ProteinPaint hg19 or hg38

Genome

View all variants in GenomePaint hg19 or hg38

Expression

References

Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S, Hansmann ML, Hoell JI, Hovestadt V, Huang B, Hummel M, Jäger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Martín-Subero JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Möller P, Loeffler M, Eils R, Klapper W, Hoffmann S, Trümper L, ICGC MMML-Seq consortium, ICGC DE-Mining consortium, BLUEPRINT consortium, Küppers R, Schlesner M, Siebert R. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021 Jul;35(7):2002–2016. PMCID: PMC8257491

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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