HNRNPD

Overview

hnRNPs are a family of RNA-binding proteins that play crucial roles in RNA processing, including splicing, stability, transport, and translation. They are involved in the regulation of gene expression at multiple levels. HNRNPD mutations are rare in DLBCL. The mutation pattern in DLBCL and FL implies the preferential accumulation of inactivating mutations. Without further support, this gene may be migrated to Tier 2.

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence DLBCL gene
	2	relevance in FL not firmly established

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	2.10
DLBCL	Schmitz cohort	2.13
DLBCL	Reddy cohort	1.80
DLBCL	Chapuy cohort	0.85
FL	GAMBL genomes	NA

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	0.000	19.81
DLBCL	No	No	1.554	0.00
FL	No	No	0.000	0.00

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

## HNRNPD Expression

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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