Table of Contents

Relevance tier by entity

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Mutation incidence

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 37 0.0340 [0.0232,0.0447]
DLBCL GAMBL with Reddy 2,088 61 0.0292 [0.022,0.0364]
DLBCL BC 231 8 0.0346 [0.0111,0.0582]
DLBCL Dana-Farber 303 10 0.0330 [0.0129,0.0531]
DLBCL NCI 470 16 0.0340 [0.0176,0.0504]
DLBCL Reddy 999 24 0.0240 [0.0145,0.0335]
DLBCL DLBCL_ICGC 85 3 0.0353 [0,0.0745]
pathology Collection N mutated Incidence CI
BL GAMBL without Panea 309 15 0.0038 [0,0.0106]
BL GAMBL without ICGC/Zhou 320 24 0.0740 [0.0453,0.1026]
BL GAMBL with Panea 410 24 0.0051 [0,0.0118]
BL BLGSP 219 15 0.0685 [0.035,0.1019]
BL Zhou/ICGC 90 0 0.0011 [0,0.008]
BL Panea 101 9 0.0891 [0.0335,0.1447]

Mutation pattern

Entity Missense dN/dS Nonsense dN/dS Q value
BL 0.8463 24.2455 0
FL 1.6357 21.6216 0
DLBCL 0.8871 4.3802 0

aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chr1 245023502 245029083 TSS NA

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1.
Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;
2.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481–494.e15. PMCID: PMC5659841

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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