Table of Contents

Relevance tier by entity

Entity Tier Description
BL 1 High-confidence BL gene
DLBCL 1 High-confidence DLBCL gene

Mutation incidence

DLBCL

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 37 0.0340 [0.0232,0.0447]
DLBCL GAMBL with Reddy 2,088 61 0.0292 [0.022,0.0364]
DLBCL BC 231 8 0.0346 [0.0111,0.0582]
DLBCL Dana-Farber 303 10 0.0330 [0.0129,0.0531]
DLBCL NCI 470 16 0.0340 [0.0176,0.0504]
DLBCL Reddy 999 24 0.0240 [0.0145,0.0335]
DLBCL DLBCL_ICGC 85 3 0.0353 [0,0.0745]

BL

pathology Collection N mutated Incidence CI
BL GAMBL without Panea 309 15 0.0038 [0,0.0106]
BL GAMBL without ICGC/Zhou 320 24 0.0740 [0.0453,0.1026]
BL GAMBL with Panea 410 24 0.0051 [0,0.0118]
BL BLGSP 219 15 0.0685 [0.035,0.1019]
BL Zhou/ICGC 90 0 0.0011 [0,0.008]
BL Panea 101 9 0.0891 [0.0335,0.1447]

FL

pathology Collection N mutated Incidence CI
FL GAMBL without Crouch 642 21 0.0327 [0.019,0.0465]
FL GAMBL with Crouch 1,189 21 0.0177 [0.0102,0.0251]
FL BC 379 14 0.0369 [0.018,0.0559]
FL Kalmbach 164 3 0.0183 [0,0.0388]
FL Crouch 547 0 0.0002 [0,0.0013]
FL FL_ICGC 99 4 0.0404 [0.0016,0.0792]

Mutation pattern

Entity Missense dN/dS Nonsense dN/dS Q value
BL 0.8463 24.2455 0
FL 1.6357 21.6216 0
DLBCL 0.8871 4.3802 0

aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chr1 245023502 245029083 TSS NA

Visualizations

Protein

View coding variants in ProteinPaint hg19 or hg38

Genome

View all variants in GenomePaint hg19 or hg38

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2017-10-10 : Reddy : DLBCL 2019-09-26 : Panea : BL

References

1.
Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;
2.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481–494.e15. PMCID: PMC5659841

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

Disclaimer

The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

Share — copy and redistribute the material in any medium or format for any purpose, even commercially.

Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.