Audit of B-cell Cancer Genes

This project tracks all genes that have been nominated as drivers (recurrent targets of mutation) in a variety of B-cell lymphomas and their level of support based on available datasets. The pattern of mutations in each gene can be found through the gene lists (below). Additional information for each gene can be found on their respective pages. To get started, select one of the gene lists from the table below then select the gene page link for any gene in the table.

B-cell Lymphoma gene lists

entity Tier 1 (high-confidence) Tier 2 (low-confidence)
DLBCL (152 genes) (173 genes)
FL (65 genes) (50 genes)
BL (29 genes) (188 genes)
MCL (24 genes) (29 genes)

Origins of B-cell lymphoma gene lists

--- config: sankey: showValues: false linkColor: target width: 800 height: 1000 nodeAlignment: right --- sankey-beta Sanger, 2001, 4 2001, pasqualucci 2001, 4 pasqualucci 2001, DLBCL Tier 1, 3 pasqualucci 2001, DLBCL Tier 2, 1 RNA-seq/exome, 2011, 49 2011, morin 2011, 25 morin 2011, DLBCL Tier 1, 25 2011, morin 2011, 15 morin 2011, FL Tier 2, 1 morin 2011, FL Tier 1, 14 2011, pasqualucci 2011a, 7 pasqualucci 2011a, DLBCL Tier 1, 5 pasqualucci 2011a, DLBCL Tier 2, 2 2011, pasqualucci 2011b, 2 pasqualucci 2011b, FL Tier 1, 2 pasqualucci 2011b, DLBCL Tier 1, 2 exome, 2012-exome, 68 2012-exome, richter 2012, 5 2012-exome, lohr 2012, 4 2012-exome, love 2012, 59 richter 2012, BL Tier 1, 5 lohr 2012, DLBCL Tier 2, 1 lohr 2012, DLBCL Tier 1, 3 love 2012, BL Tier 1, 3 love 2012, BL Tier 2, 56 RNA-seq, 2012-RNA-seq, 19 2012-RNA-seq, schmitz 2012, 19 schmitz 2012, BL Tier 1, 3 schmitz 2012, BL Tier 2, 16 WGS, 2013-WGS, 40 2013-WGS, morin 2013, 40 morin 2013, DLBCL Tier 2, 29 morin 2013, DLBCL Tier 1, 11 exome, 2013-exome, 19 2013-exome, zhang 2013, 19 zhang 2013, DLBCL Tier 1, 11 zhang 2013, DLBCL Tier 2, 8 exome, 2014-exome, 3 2014-exome, muppidi 2014, 3 muppidi 2014, BL Tier 1, 1 muppidi 2014, BL Tier 2, 2 exome, 2016-exome, 2 2016-exome, mareschal 2016, 2 mareschal 2016, DLBCL Tier 1, 2 WGS, 2016-WGS, 2 2016-WGS, okosun 2016, 2 okosun 2016, FL Tier 1, 2 exome, 2016-exome, 2 2016-exome, morin 2016, 2 morin 2016, DLBCL Tier 1, 2 exome, 2017-exome, 85 2017-exome, krysiak 2017, 22 krysiak 2017, FL Tier 2, 5 krysiak 2017, FL Tier 1, 17 2017-exome, albuquerque 2017, 3 albuquerque 2017, DLBCL Tier 1, 3 2017-exome, reddy 2017, 60 reddy 2017, DLBCL Tier 2, 50 reddy 2017, DLBCL Tier 1, 10 exome, 2018-exome, 35 2018-exome, schmitz 2018, 16 schmitz 2018, DLBCL Tier 2, 7 schmitz 2018, DLBCL Tier 1, 9 2018-exome, chapuy 2018, 19 chapuy 2018, DLBCL Tier 2, 16 chapuy 2018, DLBCL Tier 1, 3 WGS, 2018-WGS, 20 2018-WGS, arthur 2018, 20 arthur 2018, DLBCL Tier 2, 12 arthur 2018, DLBCL Tier 1, 8 RNA-seq/exome,2019-RNA-seq/exome,47 2019-RNA-seq/exome, panea 2019, 47 panea 2019, BL Tier 2, 43 panea 2019, BL Tier 1, 4 WGS,2019-WGS,13 2019-WGS, grande 2019, 13 grande 2019, BL Tier 1, 8 grande 2019, BL Tier 2, 5 exome, 2020-exome, 2 2020-exome, pararajalingam 2020, 2 pararajalingam 2020, DLBCL Tier 1, 2 WGS, 2021-WGS, 40 2021-WGS, hubschmann 2021, 17 2021-WGS, hubschmann 2021, 23 hubschmann 2021, FL Tier 2, 15 hubschmann 2021, FL Tier 1, 2 hubschmann 2021, DLBCL Tier 1, 4 hubschmann 2021, DLBCL Tier 2, 19 exome, 2023-exome, 20 2023-exome, russler 2023, 20 russler 2023, FL Tier 1, 1 russler 2023, FL Tier 2, 19 Panel, 2022-panel, 25 2022-panel, burkhardt 2022, 25 burkhardt 2022, BL Tier 2, 25 WGS, 2023-WGS, 3 2023-WGS, thomas 2023, 3 thomas 2023, BL Tier 2, 1 thomas 2023, BL Tier 1, 2

B-cell Lymphoma aSHM targets

hg19 coordinates

hg38 coordinates

B-cell lymphoma mutation browser

FOXO1

Gene expression distributions across B-cell lymphomas

expression

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

Disclaimer

The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.

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