ID3

History

ID3 was first reported as mutated in BL in 2012 by Richter et al.richterRecurrentMutationID32012a? The existence of mutations in DLBCL were described in 2012 by Schmitz et al1 and later in MZL by Spina et al.spinaGeneticsNodalMarginal2016b?

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2012-10-04 : Schmitz : DLBCL 2012-11-11 : Richter : BL 2016 : Spina : MZL

Relevance tier by entity

Entity Tier Description
BL 1 high-confidence BL generichterRecurrentMutationID32012a?
MZL 1 high-confidence MZL genespinaGeneticsNodalMarginal2016b?
DLBCL 2 Although recurrent, the relevance of mutations in DLBCL is tenuous1

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
BL GAMBL genomes+capture 45.50
BL Thomas cohort 47.00
BL Panea cohort 31.70
DLBCL GAMBL genomes 1.53
DLBCL Schmitz cohort 4.68
DLBCL Reddy cohort 3.50
DLBCL Chapuy cohort 0.85
FL GAMBL genomes 0.92

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL Yes Yes 42.419 439.808
DLBCL Yes Yes 0.000 30.520
FL Yes No 3.497 0.000

aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chr1 23885584 23885835 TSS NA

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

ID3 Expression

References

1.
Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012 Oct 4;490(7418):116–120. PMCID: PMC3609867

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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