Table of Contents

Relevance tier by entity

Entity Tier Description
DLBCL 2 Role of IKBKB mutations in DLBCL requires confirmation
MZL 2 Role of IKBKB mutations in MZL requires confirmation
PMBL 2 Role of IKBKB mutations in PMBL requires confirmation

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 0.57
DLBCL Schmitz cohort 2.98
DLBCL Reddy cohort 1.10
DLBCL Chapuy cohort 3.42

Mutation pattern and selective pressure estimates

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Expression

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References

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3.
Wienand K, Chapuy B, Stewart C, Dunford AJ, Wu D, Kim J, Kamburov A, Wood TR, Cader FZ, Ducar MD, Thorner AR, Nag A, Heubeck AT, Buonopane MJ, Redd RA, Bojarczuk K, Lawton LN, Armand P, Rodig SJ, Fromm JR, Getz G, Shipp MA. Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion. Blood Adv. 2019 Dec 10;3(23):4065–4080. PMCID: PMC6963251

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