Table of Contents
Relevance tier by entity
Cannot include /table1_IKBKB.md - does not exist yet
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 0.57 |
| DLBCL | Schmitz cohort | 2.98 |
| DLBCL | Reddy cohort | 1.10 |
| DLBCL | Chapuy cohort | 3.42 |
Mutation pattern and selective pressure estimates
| Entity | Missense dN/dS | Nonsense dN/dS | Q value |
|---|---|---|---|
| BL | 4.4066 | 0 | 1.0000 |
| FL | 3.2197 | 0 | 1.0000 |
| DLBCL | 0.0000 | 0 | 0.9986 |
Cannot include /browser_IKBKB.md - does not exist yet
Expression
History
%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
timeline
title Publication timing
2011-11-03 : Rossi : MZL
2017-10-10 : Reddy : DLBCL
2019-12-10 : Wienand : PMBL
References
1.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love
CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg
ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W,
Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y,
Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O,
Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB,
Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava
G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn
A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T,
Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional
Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017
Oct;171(2):481–494.e15. PMCID: PMC5659841
2.
Rossi D, Deaglio S, Dominguez-Sola D, Rasi S,
Vaisitti T, Agostinelli C, Spina V, Bruscaggin A, Monti S, Cerri M,
Cresta S, Fangazio M, Arcaini L, Lucioni M, Marasca R, Thieblemont C,
Capello D, Facchetti F, Kwee I, Pileri SA, Foà R, Bertoni F,
Dalla-Favera R, Pasqualucci L, Gaidano G. Alteration of
BIRC3 and multiple other NF-κB
pathway genes in splenic marginal zone lymphoma. Blood. 2011 Nov
3;118(18):4930–4934.
3.
Wienand K, Chapuy B, Stewart C, Dunford AJ, Wu
D, Kim J, Kamburov A, Wood TR, Cader FZ, Ducar MD, Thorner AR, Nag A,
Heubeck AT, Buonopane MJ, Redd RA, Bojarczuk K, Lawton LN, Armand P,
Rodig SJ, Fromm JR, Getz G, Shipp MA. Genomic analyses of flow-sorted
Hodgkin Reed-Sternberg cells reveal complementary
mechanisms of immune evasion. Blood Adv. 2019 Dec 10;3(23):4065–4080.
PMCID: PMC6963251


