[IKZF3]
Mutation tier
| Entity | Tier |
|---|---|
| BL | 2 |
| DLBCL | 2 |
Mutation incidence
| Entity | study | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 1.62 |
| BL | Thomas cohort | 0.80 |
| BL | Panea cohort | 3.00 |
| DLBCL | GAMBL genomes | 4.30 |
| DLBCL | Schmitz cohort | 4.50 |
| DLBCL | Reddy cohort | 3.90 |
| DLBCL | Chapuy cohort | 4.30 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 1.552 | 0 |
| DLBCL | Yes | No | 10.924 | 0 |
| FL | Yes | No | 7.180 | 0 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr17 | 37928959 | 37940119 | TSS-1 | NA |
| chr17 | 38015776 | 38024832 | TSS-2 | NA |
[!NOTE] First described in BL in 2019 by Panea RI. First described in DLBCL in 2017 by Mareschal S
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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