KRAS
Overview
KRAS mutations are rare but occur in some cases of DLBCL.1 These often affect the most common KRAS hotspot sites that are mutated in other solid cancers (G12 and G13).
History
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence DLBCL genelohrDiscoveryPrioritizationSomatic2012a? |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 1.91 |
| DLBCL | Schmitz cohort | 3.62 |
| DLBCL | Reddy cohort | 1.70 |
| DLBCL | Chapuy cohort | 2.56 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 27.314 | 0 |
| DLBCL | No | No | 5.336 | 0 |
| FL | No | No | 9.959 | 0 |
KRAS Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr12 | 25398285 | C>A | G12C |
| chr12 | 25398284 | C>T | G12D |
| chr12 | 25398284 | C>A | G12V |
| chr12 | 25398282 | C>A | G13C |
| chr12 | 25398281 | C>T | G13D |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
KRAS Expression
References
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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