Table of Contents

Relevance tier by entity

Entity Tier Description
DLBCL 2 Role of LPP mutations in DLBCL requires confirmation

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 1.15
DLBCL Schmitz cohort 1.28
DLBCL Reddy cohort 1.30
DLBCL Chapuy cohort 0.85

Mutation pattern and selective pressure estimates

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aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chr3 187771678 187801626 TSS-1 NA
chr3 187801627 187813568 TSS-2 NA
chr3 187813569 187955254 TSS-3 NA
chr3 187955255 187969220 TSS-4 NA
chr3 188261523 188327097 TSS-5 NA
chr3 188377178 188401951 intron-1 NA
chr3 188401952 188461879 intron-2 NA
chr3 188461880 188474683 intron-3 NA
chr3 188474684 188491248 intron-4 NA

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Expression

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References

1.
Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma. Nat Commun. 2018 Oct 1;9(1):4001. PMCID: PMC6167379

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