LPP

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2018-10-01 : Arthur : DLBCL

Relevance tier by entity

Entity Tier Description
DLBCL 2 aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous1

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 1.15
DLBCL Schmitz cohort 1.28
DLBCL Reddy cohort 1.30
DLBCL Chapuy cohort 0.85

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL Yes No 0 0
DLBCL Yes No 0 0
FL Yes No 0 0

aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chr3 187771678 187801626 TSS-1 NA
chr3 187801627 187813568 TSS-2 NA
chr3 187813569 187955254 TSS-3 NA
chr3 187955255 187969220 TSS-4 NA
chr3 188261523 188327097 TSS-5 NA
chr3 188377178 188401951 intron-1 NA
chr3 188401952 188461879 intron-2 NA
chr3 188461880 188474683 intron-3 NA
chr3 188474684 188491248 intron-4 NA

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

LPP Expression

References

1.
Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma. Nat Commun. 2018 Oct 1;9(1):4001. PMCID: PMC6167379

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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