Table of Contents
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in PMBL/cHL/GZL not firmly established1 |
 |
1 | High-confidence DLBCL gene2,3 |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Cannot include /DLBCL_LRRN3.md - does not exist yet
Mutation pattern and selective pressure estimates
Cannot include /dnds_LRRN3.md - does not exist yet
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
LRRN3 Expression
All Mutations
Cannot include /mermaid_LRRN3.md - does not exist yet
References
1.
Sarkozy C, Hung SS, Chavez EA, Duns G, Takata
K, Chong LC, Aoki T, Jiang A, Miyata-Takata T, Telenius A, Slack GW,
Molina TJ, Ben-Neriah S, Farinha P, Dartigues P, Damotte D, Mottok A,
Salles GA, Casasnovas RO, Savage KJ, Laurent C, Scott DW,
Traverse-Glehen A, Steidl C. Mutational landscape of
gray zone lymphoma. Blood. 2021 Apr 1;137(13):1765–1776.
2.
Zhang J, Grubor V, Love CL, Banerjee A,
Richards KL, Mieczkowski PA, Dunphy C, Choi W, Au WY, Srivastava G,
Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers C,
Naresh K, Evens A, Gordon LI, Czader M, Gill JI, Hsi ED, Liu Q, Fan A,
Walsh K, Jima D, Smith LL, Johnson AJ, Byrd JC, Luftig MA, Ni T, Zhu J,
Chadburn A, Levy S, Dunson D, Dave SS. Genetic heterogeneity of diffuse
large B-cell lymphoma. Proceedings of the
National Academy of Sciences of the United States of America.
2013;110:1398–1403. PMCID: PMC3557051
3.
Morin RD, Mungall K, Pleasance E, Mungall AJ,
Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC,
Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A,
Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL,
Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors
JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse
large B-cell lymphoma using whole-genome
sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992