Table of Contents

Relevance tier by entity

Entity Tier Description
FL 2 Role of MAGEC1 mutations in FL requires confirmation

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
FL GAMBL genomes 1.85

Mutation pattern and selective pressure estimates

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MAGEC1 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chrX 140993821 T>G L211V
chrX 140993827 A>C I213L
chrX 140994066 G>C Q292H
chrX 140994280 A>G T364A

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Expression

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References

1.
Russler-Germain DA, Krysiak K, Ramirez CA, Mosior M, Watkins MP, Gomez F, Skidmore ZL, Trani L, Gao F, Geyer S, Cashen A, Mehta-Shah N, Kahl B, Bartlett N, Alderuccio J, Lossos I, Ondrejka S, Hsi E, Martin P, Leonard J, Griffith M, Griffith O, Fehniger T. Mutations associated with progression in follicular lymphoma predict inferior outcomes at diagnosis: Alliance A151303. Blood Advances. 2023;7:5524–5539.

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