MAP2K1

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2015-03-01 : Shin : DLBCL 2016-08-25 : Louissaint : FL

Relevance tier by entity

Entity Tier Description
DLBCL 2 relevance in DLBCL not firmly established1
FL 1 high-confidence FL genelouissaintPediatrictypeNodalFollicular2016a?

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 1.34
DLBCL Schmitz cohort 3.19
DLBCL Reddy cohort 2.20
DLBCL Chapuy cohort 2.14
FL GAMBL genomes 1.39

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 4.318 0
DLBCL No No 11.932 0
FL No No 5.696 0

MAP2K1 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr15 66727441 T>C F53L
chr15 66727454 A>C K57T

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

MAP2K1 Expression

References

1.
Shin SY, Lee ST, Kim HJ, Ki CS, Jung CW, Kim JW, Kim SH. BRAF V600E and MAP2K1 mutations in hairy cell leukemia and splenic marginal zone lymphoma cases. Ann Lab Med. 2015 Mar;35(2):257–259. PMCID: PMC4330180

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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