MCL1

Overview

MCL1 (Myeloid Cell Leukemia 1) is a member of the BCL2 family of proteins that play a critical role in inhibiting apoptosis. It is frequently overexpressed and sometimes mutated in DLBCL.^1,2 MCL1 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.

Relevance tier by entity

Entity	Tier	Description
BL	2-a	aSHM target; Although recurrent, the relevance of mutations in BL is tenuous
DLBCL	1-a	aSHM target and high-confidence DLBCL gene

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
BL	GAMBL genomes+capture	1.85
BL	Thomas cohort	2.10
BL	Panea cohort	2.00
DLBCL	GAMBL genomes	2.49
DLBCL	Schmitz cohort	3.62
DLBCL	Reddy cohort	4.70
DLBCL	Chapuy cohort	3.42

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	Yes	No	5.101	0.000
DLBCL	Yes	No	0.427	2.401
FL	Yes	No	0.000	0.000

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr1	150550814	150552135	intron	NA

[!NOTE] First described in BL in 2019 by Panea RI. First described in DLBCL in 2017 by Reddy A

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

MCL1 Expression

References

1. Wenzel, S., Grau, M., Mavis, C., Hailfinger, S., Wolf, A., Madle, H., Deeb, G., Dörken, B., Thome, M., Lenz, P., Dirnhofer, S., Hernandez-Ilizaliturri, F., Tzankov, A., & Lenz, G. (2013). MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma. Leukemia, 27, 1381-1390. https://doi.org/10.1038/leu.2012.367.