Origins of MCL genes

Tier 1 MCL genes

23 total

Gene Tier First MCL evidence Other entities
ATM 1 Bea et al1 2,3
BIRC3 1 Bea et al1 4,dunsCharacterizationDLBCLPMBL2021b?,rossiAlterationBIRC3Multiple2011a?
CARD11 1 Wu et al5 6,7,yanBCRTLRSignaling2012a?
CCND1 1 Bea et al1
DAZAP1 1 Pararajalingam et al8
EWSR1 1 Pararajalingam et al8
HNRNPH1 1 Pararajalingam et al8
KMT2D 1 Bea et al1 7,9,10,rossiCodingGenomeSplenic2012c?
MEF2B 1 Bea et al1 7
NFKBIE 1 Pararajalingam et al8 11,12
NOTCH1 1 Bea et al1 13,14,rossiCodingGenomeSplenic2012c?
NOTCH2 1 Bea et al1 15,rossiCodingGenomeSplenic2012c?
NSD2 1 Bea et al1 15
POT1 1 Zhang et al16
RB1 1 Zhang et al16 17
S1PR1 1 Pararajalingam et al8 lohrDiscoveryPrioritizationSomatic2012a?
SMARCA4 1 Nadeu et alnadeuGenomicEpigenomicInsights2020b? richterRecurrentMutationID32012a?,lohrDiscoveryPrioritizationSomatic2012a?,krysiakRecurrentSomaticMutations2017b?
SP140 1 Bea et al1
SYNE1 1 Nadeu et alnadeuGenomicEpigenomicInsights2020b?
TERT 1 Nadeu et alnadeuGenomicEpigenomicInsights2020b?
TLR2 1 Bea et al1 chapuyMolecularSubtypesDiffuse2018b?
TP53 1 Bea et al1 7,18,tiacciPervasiveMutationsJAKSTAT2018b?,rossiCodingGenomeSplenic2012c?,lohrDiscoveryPrioritizationSomatic2012a?
UBR5 1 Pararajalingam et al8 15

Tier 2 MCL genes

46 total

Gene Tier First MCL evidence Other entities
ABCA3 2 Bea et al1 15
ABCC9 2 Bea et al1
ANK2 2 Zhang et al16 15
ARID1B 2 3
ATP11C 2 Zhang et al16
B2M 2 Pararajalingam et al8 7,reichelFlowSortingExome2015a?
BCOR 2 Nadeu et alnadeuGenomicEpigenomicInsights2020b? 19
CDH8 2 Zhang et al16 3
CHMP4C 2 Bea et al1
COL11A1 2 Zhang et al16
COL16A1 2 Zhang et al16
CRYBG3 2 Bea et al1
CTNNA2 2 Zhang et al16
DCP1B 2 Bea et al1
DHDH 2 Zhang et al16
DLC1 2 Zhang et al16
DLGAP2 2 Bea et al1
DNAJC6 2 Bea et al1
EIF2AK4 2 Zhang et al16
ESX1 2 Zhang et al16
FAT4 2 Zhang et al16 17,20
GRIN2A 2 Zhang et al16
HEPH 2 Zhang et al16
KCNC2 2 Bea et al1
KIAA1671 2 Bea et al1
KMT2C 2 Zhang et al16 15,21,sarkozyMutationalLandscapeGray2021a?
LUZP4 2 Bea et al1
MRGPRF 2 Zhang et al16
NIN 2 Zhang et al16
OGDHL 2 Zhang et al16
PCDHB2 2 Zhang et al16
PCSK2 2 Bea et al1
PDLIM3 2 Bea et al1
PLXNB3 2 Zhang et al16 spinaGeneticsNodalMarginal2016b?
RGS4 2 Bea et al1
ROBO2 2 Zhang et al16
SALL3 2 Zhang et al16 13
SI 2 Zhang et al16
SLC17A6 2 Bea et al1
SMARCB1 2 Nadeu et alnadeuGenomicEpigenomicInsights2020b?
SMC1A 2 Zhang et al16
TBC1D26 2 Zhang et al16
TNRC6B 2 Bea et al1
TRPM6 2 Bea et al1
ZNF117 2 Zhang et al16
ZNF296 2 Zhang et al16

Tier 3 MCL genes

0 total

Gene Tier First MCL evidence Other entities

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Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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