MCL genes

Origins of MCL genessankey

Tier 1 MCL genes

23 total

Gene Tier Relevant references
ATM 1 Beà et al. 2013; Reddy et al. 2017
BIRC3 1 Arthur et al. 2018; Beà et al. 2013
CARD11 1 Panea et al. 2019; Lenz et al. 2008; Wu et al. 2016; Morin et al. 2011
CCND1 1, aSHM Beà et al. 2013
DAZAP1 1 Pararajalingam et al. 2020
EWSR1 1 Pararajalingam et al. 2020
HNRNPH1 1, noncoding Pararajalingam et al. 2020
KMT2D 1 Morin et al. 2011; Beà et al. 2013; Grande et al. 2019
MEF2B 1 Beà et al. 2013; Morin et al. 2011
NFKBIE 1 Morin et al. 2016; Pararajalingam et al. 2020
NOTCH1 1 Pasqualucci et al. 2011; Love et al. 2012; Beà et al. 2013
NOTCH2 1 Panea et al. 2019; Trøen et al. 2008; Beà et al. 2013
NSD2 1 Beà et al. 2013
POT1 1 Zhang et al. 2014
RB1 1 Morin et al. 2013; Zhang et al. 2014
S1PR1 1 Pararajalingam et al. 2020
SMARCA4 1 Nadeu et al. 2020; Richter et al. 2012; Krysiak et al. 2017; Zhang et al. 2013
SP140 1 Beà et al. 2013
SYNE1 1 Nadeu et al. 2020
TERT 1, noncoding Nadeu et al. 2020
TLR2 1 Chapuy et al. 2018; Beà et al. 2013
TP53 1 Wilda et al. 2004; Morin et al. 2011; Beà et al. 2013
UBR5 1 Zhang et al. 2013; Pararajalingam et al. 2020

Tier 2 MCL genes

46 total

Gene Tier Relevant references
ABCA3 2 Beà et al. 2013
ABCC9 2 Beà et al. 2013
ANK2 2 Zhang et al. 2014
ARID1B 2 Reddy et al. 2017
ATP11C 2 Zhang et al. 2014
B2M 2 Morin et al. 2011; Pararajalingam et al. 2020
BCOR 2 Nadeu et al. 2020
CDH8 2 Zhang et al. 2014
CHMP4C 2 Beà et al. 2013
COL11A1 2 Zhang et al. 2014
COL16A1 2 Zhang et al. 2014
CRYBG3 2 Beà et al. 2013
CTNNA2 2 Zhang et al. 2014
DCP1B 2 Beà et al. 2013
DHDH 2 Zhang et al. 2014
DLC1 2 Zhang et al. 2014
DLGAP2 2 Beà et al. 2013
DNAJC6 2 Beà et al. 2013
EIF2AK4 2 Zhang et al. 2014
ESX1 2 Zhang et al. 2014
FAT4 2 Morin et al. 2013; Zhang et al. 2014
GRIN2A 2 Zhang et al. 2014
HEPH 2 Zhang et al. 2014
KCNC2 2 Beà et al. 2013
KIAA1671 2 Beà et al. 2013
KMT2C 2 Zhang et al. 2013; Zhang et al. 2014; Zhou et al. 2019
LUZP4 2 Beà et al. 2013
MRGPRF 2 Zhang et al. 2014
NIN 2 Zhang et al. 2014
OGDHL 2 Zhang et al. 2014
PCDHB2 2 Zhang et al. 2014
PCSK2 2 Beà et al. 2013
PDLIM3 2 Beà et al. 2013
PLXNB3 2 Zhang et al. 2014
RGS4 2 Beà et al. 2013
ROBO2 2 Zhang et al. 2014
SALL3 2 Zhang et al. 2014; Love et al. 2012
SI 2 Zhang et al. 2014
SLC17A6 2 Beà et al. 2013
SMARCB1 2 Nadeu et al. 2020
SMC1A 2 Zhang et al. 2014
TBC1D26 2 Zhang et al. 2014
TNRC6B 2 Beà et al. 2013
TRPM6 2 Beà et al. 2013
ZNF117 2 Zhang et al. 2014
ZNF296 2 Zhang et al. 2014

References

Arthur, Sarah E., Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, et al. 2018. “Genome-Wide Discovery of Somatic Regulatory Variants in Diffuse Large B-cell Lymphoma.” Nature Communications 9 1: 4001. https://doi.org/10.1038/s41467-018-06354-3.
Beà, Sílvia, Rafael Valdés-Mas, Alba Navarro, Itziar Salaverria, David Martín-Garcia, Pedro Jares, Eva Giné, et al. 2013. “Landscape of Somatic Mutations and Clonal Evolution in Mantle Cell Lymphoma.” Proceedings of the National Academy of Sciences 110 45: 18250–55. https://doi.org/10.1073/pnas.1314608110.
Chapuy, Bjoern, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov, Robert A. Redd, Mike S. Lawrence, et al. 2018. “Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes.” Nature Medicine 24 5: 679–90. https://doi.org/10.1038/s41591-018-0016-8.
Grande, Bruno M., Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner, Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, et al. 2019. “Genome-Wide Discovery of Somatic Coding and Noncoding Mutations in Pediatric Endemic and Sporadic Burkitt Lymphoma.” Blood 133 12: 1313–24. https://doi.org/10.1182/blood-2018-09-871418.
Krysiak, Kilannin, Felicia Gomez, Brian S. White, Matthew Matlock, Christopher A. Miller, Lee Trani, Catrina C. Fronick, et al. 2017. “Recurrent Somatic Mutations Affecting B-cell Receptor Signaling Pathway Genes in Follicular Lymphoma.” Blood 129 4: 473–83. https://doi.org/10.1182/blood-2016-07-729954.
Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George, George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma.” Science 319 5870: 1676–79.
Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of Mutations in Burkitt Lymphoma.” Nature Genetics 44 12: 1321–25. https://doi.org/10.1038/ng.2468.
Morin, Ryan D., Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, et al. 2016. “Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 22 9: 2290–300. https://doi.org/10.1158/1078-0432.CCR-15-2123.
Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011. “Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma.” Nature 476 7360: 298–303. https://doi.org/10.1038/nature10351.
Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 7: 1256–65. https://doi.org/10.1182/blood-2013-02-483727.
Nadeu, F., D. Martín-García, G. Clot, A. Díaz-Navarro, M. Duran-Ferrer, A. Navarro, Roser Vilarrasa-Blasi, et al. 2020. “Genomic and Epigenomic Insights into the Origin, Pathogenesis and Clinical Behavior of Mantle Cell Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2020005289.
Panea, R., C. Love, Jennifer R. Shingleton, Anupama Reddy, J. Bailey, A. Moormann, J. Otieno, et al. 2019. “The Whole Genome Landscape of Burkitt Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2019001880.
Pararajalingam, Prasath, Krysta M. Coyle, Sarah E. Arthur, Nicole Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, et al. 2020. “Coding and Noncoding Drivers of Mantle Cell Lymphoma Identified Through Exome and Genome Sequencing.” Blood 136 5: 572–84. https://doi.org/10.1182/blood.2019002385.
Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011. “Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics 43 9: 830–37. https://doi.org/10.1038/ng.892.
Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.” Cell 171 2: 481–494.e15.
Richter, Julia, Matthias Schlesner, Steve Hoffmann, Markus Kreuz, Ellen Leich, Birgit Burkhardt, Maciej Rosolowski, et al. 2012. “Recurrent Mutation of the ID3 Gene in Burkitt Lymphoma Identified by Integrated Genome, Exome and Transcriptome Sequencing.” Nature Genetics 44 12: 1316–20. https://doi.org/10.1038/ng.2469.
Trøen, Gunhild, Iwona Wlodarska, Abdirashid Warsame, Silvia Hernández Llodrà, Christiane De Wolf-Peeters, and Jan Delabie. 2008. “NOTCH2 Mutations in Marginal Zone Lymphoma.” Haematologica 93 7: 1107–9. https://doi.org/10.3324/haematol.11635.
Wilda, M., J. Bruch, L. Harder, D. Rawer, A. Reiter, A. Borkhardt, and W. Woessmann. 2004. “Inactivation of the ARF-MDM-2-p53 Pathway in Sporadic Burkitt’s Lymphoma in Children.” Leukemia 18 3: 584–88. https://doi.org/10.1038/sj.leu.2403254.
Wu, Chenglin, Noel Fcc de Miranda, Longyun Chen, Agata M. Wasik, Larry Mansouri, Wojciech Jurczak, Krystyna Galazka, et al. 2016. “Genetic Heterogeneity in Primary and Relapsed Mantle Cell Lymphomas: Impact of Recurrent CARD11 Mutations.” Oncotarget 7 25: 38180–90. https://doi.org/10.18632/oncotarget.9500.
Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee, Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013. “Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” January.
Zhang, Jenny, Dereje Jima, Andrea B. Moffitt, Qingquan Liu, Magdalena Czader, Eric D. Hsi, Yuri Fedoriw, et al. 2014. “The Genomic Landscape of Mantle Cell Lymphoma Is Related to the Epigenetically Determined Chromatin State of Normal B Cells.” Blood 123 19: 2988–96. https://doi.org/10.1182/blood-2013-07-517177.
Zhou, Peixun, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, et al. 2019. “Sporadic and Endemic Burkitt Lymphoma Have Frequent FOXO1 Mutations but Distinct Hotspots in the AKT Recognition Motif.” Blood Advances 3 14: 2118–27. https://doi.org/10.1182/bloodadvances.2018029546.

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Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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