Origins of MCL genes

Tier 1, high-confidence MCL genes

23 total

Gene Status First MCL study Other lists
ATM MCL Tier 1 Bea et al DLBCL, MZL
BIRC3 MCL Tier 1 Bea et al DLBCL, MZL, PMBL
CARD11 MCL Tier 1 Wu et al DLBCL, MZL, FL, BL
CCND1 MCL Tier 1 Bea et al
DAZAP1 MCL Tier 1 Pararajalingam et al DLBCL
EWSR1 MCL Tier 1 Pararajalingam et al PMBL
HNRNPH1 MCL Tier 1 Pararajalingam et al DLBCL
KMT2D MCL Tier 1 Bea et al FL, BL, DLBCL, PMBL, MZL
MEF2B MCL Tier 1 Bea et al 1
NFKBIE MCL Tier 1 Pararajalingam et al 2,3
NOTCH1 MCL Tier 1 Bea et al 4–6
NOTCH2 MCL Tier 1 Bea et al 6,7
NSD2 MCL Tier 1 Bea et al 7
POT1 MCL Tier 1 Zhang et al
RB1 MCL Tier 1 Zhang et al 8
S1PR1 MCL Tier 1 Pararajalingam et al 9
SMARCA4 MCL Tier 1 Nadeu et al 10–12
SP140 MCL Tier 1 Bea et al
SYNE1 MCL Tier 1 Nadeu et al
TERT MCL Tier 1 Nadeu et al
TLR2 MCL Tier 1 Bea et al 13
TP53 MCL Tier 1 Bea et al 1,6,14,15
UBR5 MCL Tier 1 Pararajalingam et al 16

Tier 2, low-confidence MCL genes

46 total

Gene Summary First MCL study Other entities QC result
ABCA3 Tier 2 GE17 Bea et al 7
ABCC9 Tier 2 GE17 Bea et al
ANK2 Tier 2 GE18 Zhang et al 7
ARID1B Tier 2 GE 11
ATP11C Tier 2 GE18 Zhang et al
B2M Tier 2 GE19, FE20 Pararajalingam et al 1,21
BCOR Tier 2 GE22 Nadeu et al 23
CDH8 Tier 2 GE18 Zhang et al 11
CHMP4C Tier 2 GE17 Bea et al
COL11A1 Tier 2 GE18 Zhang et al
COL16A1 Tier 2 GE18 Zhang et al
CRYBG3 Tier 2 GE17 Bea et al
CTNNA2 Tier 2 GE18 Zhang et al
DCP1B Tier 2 GE17 Bea et al
DHDH Tier 2 GE18 Zhang et al
DLC1 Tier 2 GE18 Zhang et al
DLGAP2 Tier 2 GE17 Bea et al
DNAJC6 Tier 2 GE17 Bea et al
EIF2AK4 Tier 2 GE18 Zhang et al
ESX1 Tier 2 GE18 Zhang et al
FAT4 Tier 2 GE18 Zhang et al 8,24
GRIN2A Tier 2 GE18 Zhang et al
HEPH Tier 2 GE18 Zhang et al
KCNC2 Tier 2 GE17 Bea et al
KIAA1671 Tier 2 GE17 Bea et al
KMT2C Tier 2 GE18 Zhang et al 7,25,26
LUZP4 Tier 2 GE17 Bea et al
MRGPRF Tier 2 GE18 Zhang et al
NIN Tier 2 GE18 Zhang et al
OGDHL Tier 2 GE18 Zhang et al
PCDHB2 Tier 2 GE18 Zhang et al
PCSK2 Tier 2 GE17 Bea et al
PDLIM3 Tier 2 GE17 Bea et al
PLXNB3 Tier 2 GE18 Zhang et al 27
RGS4 Tier 2 GE17 Bea et al
ROBO2 Tier 2 GE18 Zhang et al
SALL3 Tier 2 GE18 Zhang et al 4
SI Tier 2 GE18 Zhang et al
SLC17A6 Tier 2 GE17 Bea et al
SMARCB1 Tier 2 GE22 Nadeu et al
SMC1A Tier 2 GE18 Zhang et al
TBC1D26 Tier 2 GE18 Zhang et al
TNRC6B Tier 2 GE17 Bea et al
TRPM6 Tier 2 GE17 Bea et al
ZNF117 Tier 2 GE18 Zhang et al
ZNF296 Tier 2 GE18 Zhang et al

Tier 3, retired MCL genes

0 total

Gene Summary First MCL study Other entities QC result

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Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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