Origins of MCL genes

--- config: sankey: showValues: false linkColor: target width: 800 height: 1000 nodeAlignment: right --- sankey-beta Zhang 2014, MCL Tier 1, 2 Zhang 2014, MCL Tier 2, 26 Nadeu 2020, MCL Tier 1, 3 Nadeu 2020, MCL Tier 2, 2 Pararajalingam 2020, MCL Tier 1, 6 Pararajalingam 2020, MCL Tier 2, 1 Bea 2013, MCL Tier 1, 11 Bea 2013, MCL Tier 2, 16 MCL, exome, 28 exome, Zhang 2014, 28 MCL, WGS/exome, 7 WGS/exome, Pararajalingam 2020, 7 MCL, WGS, 5 WGS, Nadeu 2020, 5 MCL, WGS/exome, 27 WGS/exome, Bea 2013, 27

Tier 1 MCL genes

23 total

Gene Tier First MCL evidence Other entities
ATM 1 Bea et al1 2,3
BIRC3 1 Bea et al1 4,dunsCharacterizationDLBCLPMBL2021b?,rossiAlterationBIRC3Multiple2011a?
CARD11 1 Wu et al5 6–8,yanBCRTLRSignaling2012a?
CCND1 1 Bea et al1
DAZAP1 1 Pararajalingam et al9
EWSR1 1 Pararajalingam et al9
HNRNPH1 1-EE Pararajalingam et al9
KMT2D 1 Bea et al1 8,10,11,rossiCodingGenomeSplenic2012c?
MEF2B 1 Bea et al1 8
NFKBIE 1 Pararajalingam et al9 12,13
NOTCH1 1 Bea et al1 14,15,rossiCodingGenomeSplenic2012c?
NOTCH2 1 Bea et al1 6,16,rossiCodingGenomeSplenic2012c?
NSD2 1 Bea et al1
POT1 1 Zhang et al17
RB1 1 Zhang et al17 18
S1PR1 1 Pararajalingam et al9 lohrDiscoveryPrioritizationSomatic2012a?
SMARCA4 1 Nadeu et alnadeuGenomicEpigenomicInsights2020b? krysiakRecurrentSomaticMutations2017b?,richterRecurrentMutationID32012a?,lohrDiscoveryPrioritizationSomatic2012a?
SP140 1 Bea et al1
SYNE1 1 Nadeu et alnadeuGenomicEpigenomicInsights2020b?
TERT 1, noncoding Nadeu et alnadeuGenomicEpigenomicInsights2020b?
TLR2 1 Bea et al1 chapuyMolecularSubtypesDiffuse2018b?
TP53 1 Bea et al1 8,19,tiacciPervasiveMutationsJAKSTAT2018b?,lohrDiscoveryPrioritizationSomatic2012a?,rossiCodingGenomeSplenic2012c?
UBR5 1 Pararajalingam et al9 20

Tier 2 MCL genes

46 total

Gene Tier First MCL evidence Other entities
ABCA3 2 Bea et al1
ABCC9 2 Bea et al1
ANK2 2 Zhang et al17
ARID1B 2 2
ATP11C 2 Zhang et al17
B2M 2 Pararajalingam et al9 8,reichelFlowSortingExome2015a?
BCOR 2 Nadeu et alnadeuGenomicEpigenomicInsights2020b? 21
CDH8 2 Zhang et al17
CHMP4C 2 Bea et al1
COL11A1 2 Zhang et al17
COL16A1 2 Zhang et al17
CRYBG3 2 Bea et al1
CTNNA2 2 Zhang et al17
DCP1B 2 Bea et al1
DHDH 2 Zhang et al17
DLC1 2 Zhang et al17
DLGAP2 2 Bea et al1
DNAJC6 2 Bea et al1
EIF2AK4 2 Zhang et al17
ESX1 2 Zhang et al17
FAT4 2 Zhang et al17 18,22
GRIN2A 2 Zhang et al17
HEPH 2 Zhang et al17
KCNC2 2 Bea et al1
KIAA1671 2 Bea et al1
KMT2C 2 Zhang et al17 20,23,sarkozyMutationalLandscapeGray2021a?
LUZP4 2 Bea et al1
MRGPRF 2 Zhang et al17
NIN 2 Zhang et al17
OGDHL 2 Zhang et al17
PCDHB2 2 Zhang et al17
PCSK2 2 Bea et al1
PDLIM3 2 Bea et al1
PLXNB3 2 Zhang et al17 spinaGeneticsNodalMarginal2016b?
RGS4 2 Bea et al1
ROBO2 2 Zhang et al17
SALL3 2 Zhang et al17 15
SI 2 Zhang et al17
SLC17A6 2 Bea et al1
SMARCB1 2 Nadeu et alnadeuGenomicEpigenomicInsights2020b?
SMC1A 2 Zhang et al17
TBC1D26 2 Zhang et al17
TNRC6B 2 Bea et al1
TRPM6 2 Bea et al1
ZNF117 2 Zhang et al17
ZNF296 2 Zhang et al17

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Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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