MCL genes

Origins of MCL genes

--- config: sankey: showValues: false linkColor: target width: 800 height: 1000 nodeAlignment: right --- sankey-beta Zhang 2014, MCL Tier 1, 2 Zhang 2014, MCL Tier 2, 26 Nadeu 2020, MCL Tier 1, 3 Nadeu 2020, MCL Tier 2, 2 Pararajalingam 2020, MCL Tier 1, 6 Pararajalingam 2020, MCL Tier 2, 1 Bea 2013, MCL Tier 1, 11 Bea 2013, MCL Tier 2, 16 MCL, exome, 28 exome, Zhang 2014, 28 MCL, WGS/exome, 7 WGS/exome, Pararajalingam 2020, 7 MCL, WGS, 5 WGS, Nadeu 2020, 5 MCL, WGS/exome, 27 WGS/exome, Bea 2013, 27

Tier 1 MCL genes

23 total

Gene	Tier	Relevant references
ATM	1	Beà et al. 2013; Braggio et al. 2012; Reddy et al. 2017
BIRC3	1	Duns et al. 2021; Rossi et al. 2011; Arthur et al. 2018; Beà et al. 2013
CARD11	1	Wu et al. 2016; Panea et al. 2019; Morin et al. 2011; Yan et al. 2012; Lenz et al. 2008
CCND1	1, aSHM	Beà et al. 2013
DAZAP1	1	Pararajalingam et al. 2020
EWSR1	1	Pararajalingam et al. 2020
HNRNPH1	1, noncoding	Pararajalingam et al. 2020
KMT2D	1	Grande et al. 2019; Beà et al. 2013; Morin et al. 2011; Desch et al. 2020; Rossi et al. 2012
MEF2B	1	Beà et al. 2013; Morin et al. 2011
NFKBIE	1	Mansouri et al. 2016; Pararajalingam et al. 2020; Morin et al. 2016
NOTCH1	1	Rossi et al. 2012; Love et al. 2012; Pasqualucci et al. 2011; Beà et al. 2013
NOTCH2	1	Trøen et al. 2008; Beà et al. 2013; Rossi et al. 2012; Panea et al. 2019
NSD2	1	Beà et al. 2013
POT1	1	Zhang et al. 2014
RB1	1	Zhang et al. 2014; Morin et al. 2013
S1PR1	1	Pararajalingam et al. 2020
SMARCA4	1	Nadeu et al. 2020; Zhang et al. 2013; Krysiak et al. 2017; Richter et al. 2012
SP140	1	Beà et al. 2013
SYNE1	1	Nadeu et al. 2020
TERT	1, noncoding	Nadeu et al. 2020
TLR2	1	Chapuy et al. 2018; Beà et al. 2013
TP53	1	Rossi et al. 2012; Wilda et al. 2004; Morin et al. 2011; Tiacci et al. 2018; Beà et al. 2013
UBR5	1	Pararajalingam et al. 2020; Zhang et al. 2013

Tier 2 MCL genes

46 total

Gene	Tier	Relevant references
ABCA3	2	Beà et al. 2013
ABCC9	2	Beà et al. 2013
ANK2	2	Zhang et al. 2014
ARID1B	2	Reddy et al. 2017
ATP11C	2	Zhang et al. 2014
B2M	2	Pararajalingam et al. 2020; Reichel et al. 2015; Morin et al. 2011
BCOR	2	Nadeu et al. 2020; Jallades et al. 2017
CDH8	2	Zhang et al. 2014
CHMP4C	2	Beà et al. 2013
COL11A1	2	Zhang et al. 2014
COL16A1	2	Zhang et al. 2014
CRYBG3	2	Beà et al. 2013
CTNNA2	2	Zhang et al. 2014
DCP1B	2	Beà et al. 2013
DHDH	2	Zhang et al. 2014
DLC1	2	Zhang et al. 2014
DLGAP2	2	Beà et al. 2013
DNAJC6	2	Beà et al. 2013
EIF2AK4	2	Zhang et al. 2014
ESX1	2	Zhang et al. 2014
FAT4	2	Parry et al. 2013; Zhang et al. 2014; Morin et al. 2013
GRIN2A	2	Zhang et al. 2014
HEPH	2	Zhang et al. 2014
KCNC2	2	Beà et al. 2013
KIAA1671	2	Beà et al. 2013
KMT2C	2	Sarkozy et al. 2021; Zhang et al. 2014; Zhang et al. 2013; Zhou et al. 2019
LUZP4	2	Beà et al. 2013
MRGPRF	2	Zhang et al. 2014
NIN	2	Zhang et al. 2014
OGDHL	2	Zhang et al. 2014
PCDHB2	2	Zhang et al. 2014
PCSK2	2	Beà et al. 2013
PDLIM3	2	Beà et al. 2013
PLXNB3	2	Spina et al. 2016; Zhang et al. 2014
RGS4	2	Beà et al. 2013
ROBO2	2	Zhang et al. 2014
SALL3	2	Love et al. 2012; Zhang et al. 2014
SI	2	Zhang et al. 2014
SLC17A6	2	Beà et al. 2013
SMARCB1	2	Nadeu et al. 2020
SMC1A	2	Zhang et al. 2014
TBC1D26	2	Zhang et al. 2014
TNRC6B	2	Beà et al. 2013
TRPM6	2	Beà et al. 2013
ZNF117	2	Zhang et al. 2014
ZNF296	2	Zhang et al. 2014

References

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Beà, Sílvia, Rafael Valdés-Mas, Alba Navarro, Itziar Salaverria, David Martín-Garcia, Pedro Jares, Eva Giné, et al. 2013. “Landscape of Somatic Mutations and Clonal Evolution in Mantle Cell Lymphoma.” Proceedings of the National Academy of Sciences 110 45: 18250–55. https://doi.org/10.1073/pnas.1314608110.

Braggio, Esteban, Ahmet Dogan, Jonathan J. Keats, Wee J. Chng, Gaofeng Huang, Julie M. Matthews, Matthew J. Maurer, et al. 2012. “Genomic Analysis of Marginal Zone and Lymphoplasmacytic Lymphomas Identified Common and Disease-Specific Abnormalities.” Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc 25 5: 651–60. https://doi.org/10.1038/modpathol.2011.213.

Chapuy, Bjoern, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov, Robert A. Redd, Mike S. Lawrence, et al. 2018. “Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes.” Nature Medicine 24 5: 679–90. https://doi.org/10.1038/s41591-018-0016-8.

Desch, Ann-Kathrin, Kristin Hartung, Ante Botzen, Alexander Brobeil, Mathias Rummel, Lars Kurch, Thomas Georgi, et al. 2020. “Genotyping Circulating Tumor DNA of Pediatric Hodgkin Lymphoma.” Leukemia 34 1: 151–66. https://doi.org/10.1038/s41375-019-0541-6.

Duns, Gerben, Elena Viganò, Daisuke Ennishi, Clementine Sarkozy, Stacy S. Hung, Elizabeth Chavez, Katsuyoshi Takata, et al. 2021. “Characterization of DLBCL with a PMBL Gene Expression Signature.” Blood 138 2: 136–48. https://doi.org/10.1182/blood.2020007683.

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Jallades, Laurent, Lucile Baseggio, Pierre Sujobert, Sarah Huet, Kaddour Chabane, Evelyne Callet-Bauchu, Aurélie Verney, et al. 2017. “Exome Sequencing Identifies Recurrent BCOR Alterations and the Absence of KLF2, TNFAIP3 and MYD88 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma.” Haematologica 102 10: 1758–66. https://doi.org/10.3324/haematol.2016.160192.

Krysiak, Kilannin, Felicia Gomez, Brian S. White, Matthew Matlock, Christopher A. Miller, Lee Trani, Catrina C. Fronick, et al. 2017. “Recurrent Somatic Mutations Affecting B-cell Receptor Signaling Pathway Genes in Follicular Lymphoma.” Blood 129 4: 473–83. https://doi.org/10.1182/blood-2016-07-729954.

Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George, George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic CARD11 Mutations in Human Diffuse Large B Cell Lymphoma.” Science 319 5870: 1676–79.

Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of Mutations in Burkitt Lymphoma.” Nature Genetics 44 12: 1321–25. https://doi.org/10.1038/ng.2468.

Mansouri, Larry, Daniel Noerenberg, Emma Young, Elena Mylonas, Maysaa Abdulla, Mareike Frick, Fazila Asmar, et al. 2016. “Frequent NFKBIE Deletions Are Associated with Poor Outcome in Primary Mediastinal B-cell Lymphoma.” Blood 128 23: 2666–70. https://doi.org/10.1182/blood-2016-03-704528.

Morin, Ryan D., Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, et al. 2016. “Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 22 9: 2290–300. https://doi.org/10.1158/1078-0432.CCR-15-2123.

Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011. “Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma.” Nature 476 7360: 298–303. https://doi.org/10.1038/nature10351.

Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 7: 1256–65. https://doi.org/10.1182/blood-2013-02-483727.

Nadeu, F., D. Martín-García, G. Clot, A. Díaz-Navarro, M. Duran-Ferrer, A. Navarro, Roser Vilarrasa-Blasi, et al. 2020. “Genomic and Epigenomic Insights into the Origin, Pathogenesis and Clinical Behavior of Mantle Cell Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2020005289.

Panea, R., C. Love, Jennifer R. Shingleton, Anupama Reddy, J. Bailey, A. Moormann, J. Otieno, et al. 2019. “The Whole Genome Landscape of Burkitt Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2019001880.

Pararajalingam, Prasath, Krysta M. Coyle, Sarah E. Arthur, Nicole Thomas, Miguel Alcaide, Barbara Meissner, Merrill Boyle, et al. 2020. “Coding and Noncoding Drivers of Mantle Cell Lymphoma Identified Through Exome and Genome Sequencing.” Blood 136 5: 572–84. https://doi.org/10.1182/blood.2019002385.

Parry, Marina, Matthew J. J. Rose-Zerilli, Jane Gibson, Sarah Ennis, Renata Walewska, Jade Forster, Helen Parker, et al. 2013. “Whole Exome Sequencing Identifies Novel Recurrently Mutated Genes in Patients with Splenic Marginal Zone Lymphoma.” PloS One 8 12: e83244. https://doi.org/10.1371/journal.pone.0083244.

Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011. “Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics 43 9: 830–37. https://doi.org/10.1038/ng.892.

Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. “Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.” Cell 171 2: 481–494.e15.

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Richter, Julia, Matthias Schlesner, Steve Hoffmann, Markus Kreuz, Ellen Leich, Birgit Burkhardt, Maciej Rosolowski, et al. 2012. “Recurrent Mutation of the ID3 Gene in Burkitt Lymphoma Identified by Integrated Genome, Exome and Transcriptome Sequencing.” Nature Genetics 44 12: 1316–20. https://doi.org/10.1038/ng.2469.

Rossi, Davide, Silvia Deaglio, David Dominguez-Sola, Silvia Rasi, Tiziana Vaisitti, Claudio Agostinelli, Valeria Spina, et al. 2011. “Alteration of BIRC3 and Multiple Other NF-κB Pathway Genes in Splenic Marginal Zone Lymphoma.” Blood 118 18: 4930–34. https://doi.org/10.1182/blood-2011-06-359166.

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Zhang, Jenny, Dereje Jima, Andrea B. Moffitt, Qingquan Liu, Magdalena Czader, Eric D. Hsi, Yuri Fedoriw, et al. 2014. “The Genomic Landscape of Mantle Cell Lymphoma Is Related to the Epigenetically Determined Chromatin State of Normal B Cells.” Blood 123 19: 2988–96. https://doi.org/10.1182/blood-2013-07-517177.

Zhou, Peixun, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, et al. 2019. “Sporadic and Endemic Burkitt Lymphoma Have Frequent FOXO1 Mutations but Distinct Hotspots in the AKT Recognition Motif.” Blood Advances 3 14: 2118–27. https://doi.org/10.1182/bloodadvances.2018029546.

MCL_genes