MPDZ
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in PMBL/cHL/GZL not firmly established |
 |
2 | relevance in DLBCL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 6.31 |
| DLBCL | Schmitz cohort | 11.70 |
| DLBCL | Reddy cohort | 5.61 |
| DLBCL | Chapuy cohort | 2.99 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 2.932 | 8.789 |
| DLBCL | No | No | 0.632 | 1.772 |
| FL | No | No | 2.769 | 0.000 |
[!NOTE] First described in DLBCL in 2013 by Morin RD
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## MPDZ
Expression 
## References 1. Morin RD,
Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J,
Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL,
Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J,
Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S,
Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD,
Marra MA. Mutational and structural analysis of diffuse large B-cell
lymphoma using whole-genome sequencing. Blood. 2013 Aug
15;122(7):1256–1265. PMCID: PMC3744992 2. Reichel J, Chadburn A,
Rubinstein PG, Giulino-Roth L, Tam W, Liu Y, Gaiolla R, Eng K, Brody J,
Inghirami G, Carlo-Stella C, Santoro A, Rahal D, Totonchy J, Elemento O,
Cesarman E, Roshal M. Flow sorting and exome sequencing reveal the
oncogenome of primary Hodgkin and Reed-Sternberg cells. Blood. 2015 Feb
12;125(7):1061–1072. PMID: 25488972
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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