Table of Contents

Relevance tier by entity

Entity Tier Description
DLBCL 3 Mutations are unlikely to be relevant to DLBCL

Warnings

The variants reported in this gene in DLBCL failed QC

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 1.72
DLBCL Schmitz cohort 0.85
DLBCL Reddy cohort 1.50
DLBCL Chapuy cohort 0.43

Mutation pattern and selective pressure estimates

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Expression

All Mutations

Reddy_2093T Reddy_2106T Reddy_2107T Reddy_2208T Reddy_2224T Reddy_2256T Reddy_2271T Reddy_2483T Reddy_2602T Reddy_2646T Reddy_2784T Reddy_2805T Reddy_2808T Reddy_2838T Reddy_2909T Reddy_2917T Reddy_2936T Reddy_2956T Reddy_3405T Reddy_3453T Reddy_3456T Reddy_3488T Reddy_3585T Reddy_3609T Reddy_3620T Reddy_3622T Reddy_3629T Reddy_3638T Reddy_3674T Reddy_3823T Reddy_3919T Reddy_3930T Reddy_3932T Reddy_3963T Reddy_658T Reddy_799T

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References

1.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481–494.e15. PMCID: PMC5659841

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