Table of Contents

Relevance tier by entity

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Warnings

The variants reported in this gene in DLBCL failed QC

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 0.57
DLBCL Schmitz cohort 2.13
DLBCL Reddy cohort 1.10
DLBCL Chapuy cohort 0.85

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 2.0013 0 1.0000
FL 2.5333 0 1.0000
DLBCL 0.0000 0 0.9986

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Expression

All Mutations

Reddy_2120T Reddy_2137T Reddy_2140T Reddy_2190T Reddy_2450T Reddy_2680T Reddy_2895T Reddy_2935T Reddy_3394T Reddy_3485T Reddy_3755T Reddy_3766T Reddy_3779T Reddy_3783T Reddy_3846T Reddy_3852T Reddy_3948T Reddy_3961T Reddy_3978T Reddy_3990T

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References

1.
Desch AK, Hartung K, Botzen A, Brobeil A, Rummel M, Kurch L, Georgi T, Jox T, Bielack S, Burdach S, Classen CF, Claviez A, Debatin KM, Ebinger M, Eggert A, Faber J, Flotho C, Frühwald M, Graf N, Jorch N, Kontny U, Kramm C, Kulozik A, Kühr J, Sykora KW, Metzler M, Müller HL, Nathrath M, Nüßlein T, Paulussen M, Pekrun A, Reinhardt D, Reinhard H, Rössig C, Sauerbrey A, Schlegel PG, Schneider DT, Scheurlen W, Schweigerer L, Simon T, Suttorp M, Vorwerk P, Schmitz R, Kluge R, Mauz-Körholz C, Körholz D, Gattenlöhner S, Bräuninger A. Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma. Leukemia. 2020 Jan;34(1):151–166.

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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