[MYC]
Mutation tier
| Entity | Tier |
|---|---|
| BL | 1 |
| DLBCL | 1 |
| FL | 2 |
Mutation incidence
| Entity | study | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 61.89 |
| BL | Thomas cohort | 60.20 |
| BL | Panea cohort | 49.50 |
| DLBCL | GAMBL genomes | 9.90 |
| DLBCL | Schmitz cohort | 5.30 |
| DLBCL | Reddy cohort | 6.20 |
| DLBCL | Chapuy cohort | 6.40 |
| FL | GAMBL genomes | 0.92 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | Yes | 7.754 | 3.964 |
| DLBCL | Yes | Yes | 2.850 | 2.582 |
| FL | Yes | No | 4.998 | 0.000 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr8 | 128748352 | 128749427 | TSS | active_promoter |
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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