MYD88
History
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timeline
title Publication timing
2011-02-03 : Ngo : DLBCL
2012-04-01 : Yan : MZL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MZL gene1 |
 |
1 | high-confidence DLBCL gene2 |
 |
2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 0.46 |
| BL | Thomas cohort | 0.40 |
| BL | Panea cohort | 1.00 |
| DLBCL | GAMBL genomes | 13.38 |
| DLBCL | Schmitz cohort | 26.38 |
| DLBCL | Reddy cohort | 15.12 |
| DLBCL | Chapuy cohort | 21.37 |
| FL | GAMBL genomes | 1.85 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.809 | 0 |
| DLBCL | No | Yes | 56.390 | 0 |
| FL | No | No | 17.159 | 0 |
MYD88 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr3 | 38182641 | T>C | L265P |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
MYD88 Expression
References
1.
Yan
Q, Huang Y, Watkins AJ, Kocialkowski S, Zeng N, Hamoudi RA, Isaacson PG,
de Leval L, Wotherspoon A, Du MQ. BCR and TLR
signaling pathways are recurrently targeted by genetic changes in
splenic marginal zone lymphomas. Haematologica. 2012 Apr;97(4):595–598.
PMCID: PMC3347666
2.
Ngo
VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W,
Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A,
Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E,
Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook
JR, Weisenburger DD, Chan WC, Staudt LM. Oncogenically active
MYD88 mutations in human lymphoma. Nature. 2011 Feb
3;470(7332):115–119. PMCID: PMC5024568