Table of Contents

Overview

The prevalence of MYOM2 mutations in DLBCL varies across studies. The role of these mutations in lymphomagenesis has not been thoroughly explored.

Relevance tier by entity

Entity Tier Description
DLBCL 1 high-confidence DLBCL gene1

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 3.25
DLBCL Schmitz cohort 8.09
DLBCL Reddy cohort 3.20
DLBCL Chapuy cohort 4.27

Mutation pattern and selective pressure estimates

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View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

MYOM2 Expression

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References

1.
Pasqualucci L, Trifonov V, Fabbri G, Ma J, Rossi D, Chiarenza A, Wells VA, Grunn A, Messina M, Elliot O, Chan J, Bhagat G, Chadburn A, Gaidano G, Mullighan CG, Rabadan R, Dalla-Favera R. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet. 2011 Jul 31;43(9):830–837. PMCID: PMC3297422

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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