Table of Contents

MZL genes

Tier 1, high-confidence MZL genes

Gene Status First MZL study Other lists
ACTB MZL Tier 1 DLBCL, FL, PMBL
ARID1A MZL Tier 1 Rossi et al BL, DLBCL, FL, PMBL
ATM MZL Tier 1 Braggio et al DLBCL, MCL
BCL10 MZL Tier 1 Spina et al DLBCL, FL
BCL7A MZL Tier 1 BL, DLBCL, FL, PMBL
BIRC3 MZL Tier 1 Rossi et al DLBCL, PMBL, MCL
BRAF MZL Tier 1 BL, DLBCL
BTG1 MZL Tier 1 BL, DLBCL, FL, PMBL
CARD11 MZL Tier 1 Yan et al BL, DLBCL, FL, MCL
CCND3 MZL Tier 1 Jallades et al BL, DLBCL, FL, PMBL
CXCR4 MZL Tier 1 BL, DLBCL, FL
DTX1 MZL Tier 1 Rossi et al BL, DLBCL, PMBL
EP300 MZL Tier 1 Rossi et al DLBCL, FL
EZH2 MZL Tier 1 BL, DLBCL, FL, PMBL
FAS MZL Tier 1 Spina et al DLBCL, FL, PMBL
FAT1 MZL Tier 1 Spina et al PMBL
FOXO1 MZL Tier 1 BL, DLBCL, FL, PMBL
H1-4 MZL Tier 1
H1-5 MZL Tier 1
ID3 MZL Tier 1 Spina et al BL, DLBCL
KLF2 MZL Tier 1 Jallades et al DLBCL, FL, PMBL
KLHL6 MZL Tier 1 Ganapathi et al DLBCL, FL
KMT2D MZL Tier 1 Rossi et al BL, DLBCL, FL, PMBL, MCL
MAP3K14 MZL Tier 1 Rossi et al PMBL
MPEG1 MZL Tier 1 DLBCL
MYD88 MZL Tier 1 Yan et al DLBCL, FL
NCOR2 MZL Tier 1 Spina et al BL, PMBL
NOL9 MZL Tier 1 Spina et al DLBCL
NOTCH1 MZL Tier 1 Rossi et al BL, DLBCL, MCL
NOTCH2 MZL Tier 1 Rossi et al DLBCL, MCL
PCLO MZL Tier 1 DLBCL, PMBL
POU2AF1 MZL Tier 1 DLBCL, FL
PTPRD MZL Tier 1 Spina et al DLBCL, FL, PMBL
SIN3A MZL Tier 1 Rossi et al BL, DLBCL, PMBL
SOCS1 MZL Tier 1 DLBCL, FL, PMBL
SPEN MZL Tier 1 Rossi et al DLBCL, PMBL
STAT6 MZL Tier 1 DLBCL, FL, PMBL
TBL1XR1 MZL Tier 1 Rossi et al BL, DLBCL, FL, PMBL
TNFAIP3 MZL Tier 1 Rossi et al DLBCL, FL, PMBL
TNFRSF14 MZL Tier 1 Spina et al BL, DLBCL, FL
TP53 MZL Tier 1 Rossi et al BL, DLBCL, FL, PMBL, MCL
TRAF3 MZL Tier 1 Rossi et al DLBCL, PMBL

Tier 2, low-confidence MZL genes

Gene Status First MZL study Other lists
ABCA13 MZL Tier 2 Spina et al PMBL
ACTG1 MZL Tier 2 Spina et al DLBCL, FL, PMBL
ADD2 MZL Tier 2 Spina et al
AMN MZL Tier 2 Spina et al
AMOTL1 MZL Tier 2 Parry et al
AOC2 MZL Tier 2 Spina et al
ARHGAP20 MZL Tier 2 Jallades et al
ARHGEF15 MZL Tier 2 Jallades et al
ARHGEF17 MZL Tier 2 Jallades et al
BCOR MZL Tier 2 Jallades et al MCL
C6orf103 MZL Tier 2 Spina et al
CBFA2T3 MZL Tier 2 Parry et al
CD79A MZL Tier 2 Rossi et al BL
CD9B MZL Tier 2 Vandenbrand et al
CDC42BPB MZL Tier 2 Spina et al FL
CDKN2A MZL Tier 2 Spina et al BL, DLBCL, PMBL
CLGN MZL Tier 2 Spina et al
CNBP MZL Tier 2 Spina et al
CNKSR2 MZL Tier 2 Spina et al
CREBBP MZL Tier 2 Parry et al BL, DLBCL, FL, PMBL
DNAH5 MZL Tier 2 Jallades et al DLBCL
DNAH7 MZL Tier 2 Jallades et al
DNAI1 MZL Tier 2 Jallades et al
DOCK6 MZL Tier 2 Jallades et al
DSP MZL Tier 2 DLBCL
DTNB MZL Tier 2
DTX3L MZL Tier 2 Jallades et al
EGR1 MZL Tier 2 Rossi et al FL, PMBL
EGR2 MZL Tier 2 Rossi et al
EZH1 MZL Tier 2 Jallades et al
FAT4 MZL Tier 2 Parry et al DLBCL, PMBL, MCL
FBXO11 MZL Tier 2 Parry et al BL, DLBCL
GPR98 MZL Tier 2 Spina et al
GPS2 MZL Tier 2 Rossi et al
HIST1H1D MZL Tier 2 Jallades et al DLBCL, FL, PMBL
HIST1H2AD MZL Tier 2 Jallades et al
HIST1H2AG MZL Tier 2 Rossi et al BL, DLBCL, FL
HIST1H2BK MZL Tier 2 Rossi et al BL, DLBCL
HIST4H4 MZL Tier 2 Jallades et al
HRAS MZL Tier 2 Jallades et al DLBCL
IKBKB MZL Tier 2 Rossi et al DLBCL, PMBL
KAT6A MZL Tier 2 Jallades et al
KDM6A MZL Tier 2 Jallades et al
KIF26A MZL Tier 2 Jallades et al
LRP1B MZL Tier 2 Spina et al DLBCL
MCRS1 MZL Tier 2 Rossi et al
MGA MZL Tier 2 Jallades et al DLBCL
MSL2 MZL Tier 2 Rossi et al
MYC MZL Tier 2 Jallades et al BL, DLBCL, FL, PMBL
MYLK MZL Tier 2 Jallades et al
NCOA6 MZL Tier 2 Jallades et al
NRAS MZL Tier 2 Jallades et al
PACRG MZL Tier 2 Spina et al
PARK2 MZL Tier 2 Spina et al
PLA2G4D MZL Tier 2 Parry et al
PLXNB3 MZL Tier 2 Spina et al MCL
RAF1 MZL Tier 2 Jallades et al DLBCL
RAPGEF2 MZL Tier 2 DLBCL
RCOR1 MZL Tier 2 Spina et al
RFTN1 MZL Tier 2 DLBCL, PMBL
ROCK1 MZL Tier 2 Jallades et al
RPL1L MZL Tier 2 Spina et al
SAMD5 MZL Tier 2 Spina et al
SCG3 MZL Tier 2 Spina et al
STXBP5 MZL Tier 2 Spina et al
SWAP70 MZL Tier 2 Rossi et al
TAF1 MZL Tier 2 Spina et al DLBCL
TBK1 MZL Tier 2 Jallades et al
TCTN2 MZL Tier 2 Spina et al
TNIP2 MZL Tier 2 Vandenbrand et al
TRRAP MZL Tier 2 Rossi et al DLBCL
USH2A MZL Tier 2 Parry et al
WAC MZL Tier 2 Rossi et al DLBCL
WNK1 MZL Tier 2 Jallades et al BL, DLBCL

References

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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