Origins of MZL genes

--- config: sankey: showValues: false linkColor: target width: 800 height: 550 nodeAlignment: right --- sankey-beta Vandenbrand 2017, Tier 2 MZL genes, 2 Rossi 2012, Tier 1 MZL genes, 10 Rossi 2012, Tier 2 MZL genes, 11 Yan 2012, Tier 1 MZL genes, 2 Parry 2013, Tier 2 MZL genes, 7 Spina 2016, Tier 1 MZL genes, 8 Spina 2016, Tier 2 MZL genes, 23 Jallades 2017, Tier 1 MZL genes, 2 Jallades 2017, Tier 2 MZL genes, 26 Rossi 2011, Tier 1 MZL genes, 4 Rossi 2011, Tier 2 MZL genes, 1 MZL genes, MZL-exome, 28 MZL-exome, Jallades 2017, 28 MZL genes, MZL-Sanger, 5 MZL-Sanger, Rossi 2011, 5 MZL genes, MZL-exome/panel, 31 MZL-exome/panel, Spina 2016, 31 MZL genes, MZL-exome, 21 MZL-exome, Rossi 2012, 21 MZL genes, MZL-panel, 2 MZL-panel, Vandenbrand 2017, 2 MZL genes, MZL-Panel, 2 MZL-Panel, Yan 2012, 2 MZL genes, MZL-exome, 7 MZL-exome, Parry 2013, 7

Tier 1 MZL genes

42 total

Gene Tier First MZL evidence Other entities
ACTB 1 lohrDiscoveryPrioritizationSomatic2012a?,wienandGenomicAnalysesFlowsorted2019b?
ARID1A 1 rossiCodingGenomeSplenic2012c? 1,2,krysiakRecurrentSomaticMutations2017b?,wienandGenomicAnalysesFlowsorted2019b?
ATM 1 3 4,5
BCL10 1 spinaGeneticsNodalMarginal2016b? 6,russler-germainMutationsAssociatedProgression2023b?
BCL7A 1 7,8,krysiakRecurrentSomaticMutations2017b?,reichelFlowSortingExome2015a?
BIRC3 1 rossiAlterationBIRC3Multiple2011a? 5,8,dunsCharacterizationDLBCLPMBL2021b?
BRAF 1 1,tiacciBRAFMutationsHairycell2011a?
BTG1 1 6,sarkozyMutationalLandscapeGray2021a?,burkhardtClinicalRelevanceMolecular2022b?
CARD11 1 yanBCRTLRSignaling2012a? 6,9–11
CCND3 1 12 6,13,richterRecurrentMutationID32012a?
CXCR4 1 11,14,krysiakRecurrentSomaticMutations2017b?
DTX1 1 rossiCodingGenomeSplenic2012c? 11,15,schmitzGeneticsPathogenesisDiffuse2018a?
EP300 1 rossiCodingGenomeSplenic2012c? 11,pasqualucciInactivatingMutationsAcetyltransferase2011a?
EZH2 1 1,morinSomaticMutationsAltering2010a?,mottokIntegrativeGenomicAnalysis2019b?
FAS 1 spinaGeneticsNodalMarginal2016b? 16
FAT1 1 spinaGeneticsNodalMarginal2016b?
FOXO1 1 6,17,dunsCharacterizationDLBCLPMBL2021b?
H1-4 1
H1-5 1
ID3 1 spinaGeneticsNodalMarginal2016b? 17,richterRecurrentMutationID32012a?
KLF2 1 12 13,18
KLHL6 1 19 6,11
KMT2D 1 rossiCodingGenomeSplenic2012c? 5–7,13
MAP3K14 1 rossiAlterationBIRC3Multiple2011a? ottoGeneticLesionsTRAF32012a?
MPEG1 1 20
MYD88 1 yanBCRTLRSignaling2012a? ngoOncogenicallyActiveMYD882011a?
NCOR2 1 spinaGeneticsNodalMarginal2016b? 17,sarkozyMutationalLandscapeGray2021a?
NOL9 1 spinaGeneticsNodalMarginal2016b? schmitzGeneticsPathogenesisDiffuse2018a?
NOTCH1 1 rossiCodingGenomeSplenic2012c? 1,5,18
NOTCH2 1 rossiCodingGenomeSplenic2012c? 5,11,21
PCLO 1 lohrDiscoveryPrioritizationSomatic2012a?
POU2AF1 1 krysiakRecurrentSomaticMutations2017b?
PTPRD 1 spinaGeneticsNodalMarginal2016b?
SIN3A 1 rossiCodingGenomeSplenic2012c? 7
SOCS1 1 6,wenigerMutationsTumorSuppressor2006a?
SPEN 1 rossiCodingGenomeSplenic2012c? sarkozyMutationalLandscapeGray2021a?
STAT6 1 yildizActivatingSTAT6Mutations2015c?,ritzRecurrentMutationsSTAT62009a?
TBL1XR1 1 rossiCodingGenomeSplenic2012c? 22
TNFAIP3 1 rossiAlterationBIRC3Multiple2011a? compagnoMutationsMultipleGenes2009a?,schmitzTNFAIP3A20Tumor2009a?
TNFRSF14 1 spinaGeneticsNodalMarginal2016b? 6,cheungAcquiredTNFRSF14Mutations2010a?
TP53 1 rossiCodingGenomeSplenic2012c? 5,6,23,tiacciPervasiveMutationsJAKSTAT2018b?
TRAF3 1 rossiAlterationBIRC3Multiple2011a? 18,ottoGeneticLesionsTRAF32012a?

Tier 2 MZL genes

74 total

Gene Tier First MZL evidence Other entities
ABCA13 2 spinaGeneticsNodalMarginal2016b? sarkozyMutationalLandscapeGray2021a?
ACTG1 2 spinaGeneticsNodalMarginal2016b? 13,hubschmannMutationalMechanismsShaping2021b?
ADD2 2 spinaGeneticsNodalMarginal2016b?
AMN 2 spinaGeneticsNodalMarginal2016b?
AMOTL1 2 24
AOC2 2 spinaGeneticsNodalMarginal2016b?
ARHGAP20 2 12
ARHGEF15 2 12
ARHGEF17 2 12
BCOR 2 12 nadeuGenomicEpigenomicInsights2020b?
C6orf103 2 spinaGeneticsNodalMarginal2016b?
CBFA2T3 2 24
CD79A 2 rossiCodingGenomeSplenic2012c? burkhardtClinicalRelevanceMolecular2022b?
CD9B 2 25
CDC42BPB 2 spinaGeneticsNodalMarginal2016b?
CDKN2A 2 spinaGeneticsNodalMarginal2016b? 7,20
CLGN 2 spinaGeneticsNodalMarginal2016b?
CNKSR2 2 spinaGeneticsNodalMarginal2016b?
CREBBP 2 24 1,dunsCharacterizationDLBCLPMBL2021b?,pasqualucciInactivatingMutationsAcetyltransferase2011a?
DNAH5 2 12 20
DNAH7 2 12
DNAI1 2 12
DOCK6 2 12
DSP 2
DTNB 2
DTX3L 2 12
EGR1 2 rossiCodingGenomeSplenic2012c? krysiakRecurrentSomaticMutations2017b?,reichelFlowSortingExome2015a?
EGR2 2 rossiCodingGenomeSplenic2012c?
EZH1 2 12
FAT4 2 24 20,26
FBXO11 2 24 hubschmannMutationalMechanismsShaping2021b?,richterRecurrentMutationID32012a?
GPR98 2 spinaGeneticsNodalMarginal2016b?
GPS2 2 rossiCodingGenomeSplenic2012c?
HIST1H1D 2 12 20,krysiakRecurrentSomaticMutations2017b?
HIST1H2AD 2 12
HIST1H2AG 2 rossiCodingGenomeSplenic2012c? 11,20,krysiakRecurrentSomaticMutations2017b?
HIST1H2BK 2 rossiCodingGenomeSplenic2012c? 11
HIST4H4 2 12
HRAS 2 12 4
IKBKB 2 rossiAlterationBIRC3Multiple2011a? 4,wienandGenomicAnalysesFlowsorted2019b?
KAT6A 2 12
KDM6A 2 12
KIF26A 2 12
LRP1B 2 spinaGeneticsNodalMarginal2016b?
MCRS1 2 rossiCodingGenomeSplenic2012c?
MGA 2 12 2
MSL2 2 rossiCodingGenomeSplenic2012c?
MYC 2 12 27,dunsCharacterizationDLBCLPMBL2021b?,pasqualucciHypermutationMultipleProtooncogenes2001a?
MYLK 2 12
NCOA6 2 12
NRAS 2 12
PACRG 2 spinaGeneticsNodalMarginal2016b?
PARK2 2 spinaGeneticsNodalMarginal2016b?
PLA2G4D 2 24
PLXNB3 2 spinaGeneticsNodalMarginal2016b? 26
RAF1 2 12
RAPGEF2 2
RCOR1 2 spinaGeneticsNodalMarginal2016b?
RFTN1 2 8,dunsCharacterizationDLBCLPMBL2021b?
ROCK1 2 12
RPL1L 2 spinaGeneticsNodalMarginal2016b?
SAMD5 2 spinaGeneticsNodalMarginal2016b?
SCG3 2 spinaGeneticsNodalMarginal2016b?
STXBP5 2 spinaGeneticsNodalMarginal2016b?
SWAP70 2 rossiCodingGenomeSplenic2012c?
TAF1 2 spinaGeneticsNodalMarginal2016b? 20
TBK1 2 12
TCTN2 2 spinaGeneticsNodalMarginal2016b?
TNIP2 2 25
TRRAP 2 rossiCodingGenomeSplenic2012c? 24
USH2A 2 24
WAC 2 rossiCodingGenomeSplenic2012c? 4
WNK1 2 12 28,hubschmannMutationalMechanismsShaping2021b?
ZNF9 2 spinaGeneticsNodalMarginal2016b?

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