Table of Contents

Overview

Mutations in this gene are relatively rare in DLBCL overall but show a pattern of inactivation.

Relevance tier by entity

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Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
BL GAMBL genomes+capture 6.24
BL Thomas cohort NA
BL Panea cohort NA
DLBCL GAMBL genomes 2.10
DLBCL Schmitz cohort 5.74
DLBCL Reddy cohort 3.60
DLBCL Chapuy cohort 4.27

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 0.7017 0 1.0000
FL 0.4376 0 1.0000
DLBCL 0.0000 0 0.9986

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Expression

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References

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Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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