NFKB1
Overview
Mutations in this gene are relatively rare in DLBCL overall. Some hotspots have been identified in DLBCL.
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | low-confidence DLBCL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 2.10 |
| DLBCL | Schmitz cohort | 1.28 |
| DLBCL | Reddy cohort | 1.60 |
| DLBCL | Chapuy cohort | 3.42 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.644 | 0 |
| DLBCL | No | No | 1.613 | 0 |
| FL | No | No | 4.561 | 0 |
NFKB1 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr4 | 103459054 | C>T | H67Y |
| chr4 | 103459061 | G>A | G69E |
| chr4 | 103501730 | G>A | D257N |
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Expression
