NFKB2
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in PMBL/cHL/GZL not firmly established |
 |
2 | relevance in DLBCL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 1.53 |
| DLBCL | Schmitz cohort | 1.49 |
| DLBCL | Reddy cohort | 1.40 |
| DLBCL | Chapuy cohort | 2.56 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.937 | 0.00 |
| DLBCL | No | No | 0.861 | 8.02 |
| FL | No | No | 2.873 | 0.00 |
[!NOTE] First described in DLBCL in 2017 by Reddy A
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## NFKB2
Expression 
## References 1.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S,
Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen
M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim
SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton
AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben
J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung
RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar
M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R,
Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS.
Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell.
2017 Oct;171(2):481-494.e15. 2. Mottok A, Hung SS, Chavez EA, Woolcock
B, Telenius A, Chong LC, Meissner B, Nakamura H, Rushton C, Viganò E,
Sarkozy C, Gascoyne RD, Connors JM, Ben-Neriah S, Mungall A, Marra MA,
Siebert R, Scott DW, Savage KJ, Steidl C. Integrative genomic analysis
identifies key pathogenic mechanisms in primary mediastinal large B-cell
lymphoma. Blood. 2019 Sep 5;134(10):802–813. PMID: 31292115