Table of Contents
Relevance tier by entity
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Warnings
The variants reported in this gene in DLBCL failed QC
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 1.53 |
| DLBCL | Schmitz cohort | 1.49 |
| DLBCL | Reddy cohort | 1.40 |
| DLBCL | Chapuy cohort | 2.56 |
Mutation pattern and selective pressure estimates
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Expression
All Mutations
Reddy_2124T Reddy_2525T Reddy_2538T Reddy_2613T Reddy_2637T Reddy_2643T Reddy_2681T Reddy_2761T Reddy_2765T Reddy_2884T Reddy_2918T Reddy_3582T Reddy_3617T Reddy_3639T Reddy_3737T Reddy_3754T Reddy_3825T Reddy_3839T Reddy_3933T Reddy_3936T Reddy_3996T Reddy_695T
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References
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Telenius A, Chong LC, Meissner B, Nakamura H, Rushton C, Viganò E,
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Siebert R, Scott DW, Savage KJ, Steidl C. Integrative genomic
analysis identifies key pathogenic mechanisms in primary mediastinal
large B-cell lymphoma. Blood. 2019 Sep
5;134(10):802–813.
2.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love
CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg
ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W,
Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y,
Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O,
Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB,
Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava
G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn
A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T,
Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional
Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017
Oct;171(2):481–494.e15. PMCID: PMC5659841
