[NFKBIE]
Mutation tier
| Entity | Tier | Description |
|---|---|---|
| DLBCL | 1 | high-confidence DLBCL gene |
| MCL | 1 | high-confidence MCL gene |
Mutation incidence
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 3.82 |
| DLBCL | Schmitz cohort | 5.74 |
| DLBCL | Reddy cohort | 2.90 |
| DLBCL | Chapuy cohort | 3.42 |
| MCL | GAMBL genomes | 2.84 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 2.702 | 0.000 |
| DLBCL | No | Yes | 8.732 | 58.269 |
| FL | No | No | 0.000 | 46.628 |
[!NOTE] First described in DLBCL in 2016 by Morin RD. First described in MCL in 2020 by Pararajalingam P
View coding variants in ProteinPaint hg19 or hg38
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Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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