Table of Contents
Overview
NFKBIE encodes IκBε, a negative regulator of NF-κB. Mutations in NFKBIE can disrupt this regulatory function, leading to constitutive activation of NF-κB signaling.1 Mutations are relatively common in DLBCL and MCL.2
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene1 |
 |
1 | high-confidence DLBCL gene2 |
 |
1 | high-confidence MCL gene3 |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Cannot include /DLBCL_NFKBIE.md - does not exist yet
Mutation pattern and selective pressure estimates
Cannot include /dnds_NFKBIE.md - does not exist yet
Cannot include /browser_NFKBIE.md - does not exist yet
Expression
Cannot include /mermaid_NFKBIE.md - does not exist yet
References
1.
Mansouri L, Noerenberg D, Young E, Mylonas E,
Abdulla M, Frick M, Asmar F, Ljungström V, Schneider M, Yoshida K,
Skaftason A, Pandzic T, Gonzalez B, Tasidou A, Waldhueter N,
Rivas-Delgado A, Angelopoulou M, Ziepert M, Arends CM, Couronné L, Lenze
D, Baldus CD, Bastard C, Okosun J, Fitzgibbon J, Dörken B, Drexler HG,
Roos-Weil D, Schmitt CA, Munch-Petersen HD, Zenz T, Hansmann ML,
Strefford JC, Enblad G, Bernard OA, Ralfkiaer E, Erlanson M,
Korkolopoulou P, Hultdin M, Papadaki T, Grønbæk K, Lopez-Guillermo A,
Ogawa S, Küppers R, Stamatopoulos K, Stavroyianni N, Kanellis G,
Rosenwald A, Campo E, Amini RM, Ott G, Vassilakopoulos TP, Hummel M,
Rosenquist R, Damm F. Frequent
NFKBIE deletions are associated with poor outcome in
primary mediastinal B-cell lymphoma.
Blood. 2016 Dec 8;128(23):2666–2670.
2.
Morin RD, Assouline S, Alcaide M, Mohajeri A,
Johnston RL, Chong L, Grewal J, Yu S, Fornika D, Bushell K, Nielsen TH,
Petrogiannis-Haliotis T, Crump M, Tosikyan A, Grande BM, MacDonald D,
Rousseau C, Bayat M, Sesques P, Froment R, Albuquerque M, Monczak Y,
Oros KK, Greenwood C, Riazalhosseini Y, Arseneault M, Camlioglu E,
Constantin A, Pan-Hammarstrom Q, Peng R, Mann KK, Johnson NA. Genetic
Landscapes of Relapsed and Refractory
Diffuse Large B-Cell Lymphomas. Clin Cancer Res. 2016 May
1;22(9):2290–2300.
3.
Pararajalingam P, Coyle KM, Arthur SE, Thomas
N, Alcaide M, Meissner B, Boyle M, Qureshi Q, Grande BM, Rushton C,
Slack GW, Mungall AJ, Tam CS, Agarwal R, Dawson SJ, Lenz G,
Balasubramanian S, Gascoyne RD, Steidl C, Connors J, Villa D, Audas TE,
Marra MA, Johnson NA, Scott DW, Morin RD. Coding and noncoding drivers
of mantle cell lymphoma identified through exome and genome sequencing.
Blood. 2020 Jul 30;136(5):572–584. PMCID: PMC7440974
