Table of Contents

Relevance tier by entity

Cannot include /table1_NOL9.md - does not exist yet

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 50 0.0459 [0.0335,0.0583]
DLBCL GAMBL with Reddy 2,088 63 0.0302 [0.0228,0.0375]
DLBCL BC 231 5 0.0216 [0.0029,0.0404]
DLBCL Dana-Farber 303 5 0.0165 [0.0022,0.0308]
DLBCL NCI 470 32 0.0681 [0.0453,0.0909]
DLBCL Reddy 999 13 0.0130 [0.006,0.02]
DLBCL DLBCL_ICGC 85 8 0.0941 [0.032,0.1562]

Mutation pattern and selective pressure estimates

Failed to render page: conflicting chdir during another chdir block

NOL9 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr1 6614187 G>C L126V
chr1 6614167 C>A Q132H

Cannot include /browser_NOL9.md - does not exist yet

Expression

Failed to render page: conflicting chdir during another chdir block

References

1.
Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM. Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma. N Engl J Med. 2018 Apr 12;378(15):1396–1407. PMCID: PMC6010183
2.
Spina V, Khiabanian H, Messina M, Monti S, Cascione L, Bruscaggin A, Spaccarotella E, Holmes AB, Arcaini L, Lucioni M, Tabbò F, Zairis S, Diop F, Cerri M, Chiaretti S, Marasca R, Ponzoni M, Deaglio S, Ramponi A, Tiacci E, Pasqualucci L, Paulli M, Falini B, Inghirami G, Bertoni F, Foà R, Rabadan R, Gaidano G, Rossi D. The genetics of nodal marginal zone lymphoma. Blood. 2016 Sep 8;128(10):1362–1373. PMCID: PMC5016706

Failed to render page: conflicting chdir during another chdir block