NOL9
History
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MZL gene |
 |
1 | high-confidence DLBCL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 4.97 |
| DLBCL | Schmitz cohort | 6.81 |
| DLBCL | Reddy cohort | 1.30 |
| DLBCL | Chapuy cohort | 2.14 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.514 | 0 |
| DLBCL | No | No | 4.012 | 0 |
| FL | No | No | 2.619 | 0 |
## NOL9 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr1 | 6614187 | G>C | L126V |
| chr1 | 6614167 | C>A | Q132H |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## NOL9
Expression 
## References 1. Spina V,
Khiabanian H, Messina M, Monti S, Cascione L, Bruscaggin A,
Spaccarotella E, Holmes AB, Arcaini L, Lucioni M, Tabbò F, Zairis S,
Diop F, Cerri M, Chiaretti S, Marasca R, Ponzoni M, Deaglio S, Ramponi
A, Tiacci E, Pasqualucci L, Paulli M, Falini B, Inghirami G, Bertoni F,
Foà R, Rabadan R, Gaidano G, Rossi D. The genetics of nodal marginal
zone lymphoma. Blood. 2016 Sep 8;128(10):1362–1373. 2. Schmitz R, Wright
GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M,
Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu
X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E,
Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang
Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y,
Soppet DR, Pittaluga S, Wilson WH, Staudt LM. Genetics and Pathogenesis
of Diffuse Large B-Cell Lymphoma. N Engl J Med. 2018 Apr
12;378(15):1396–1407. PMCID: PMC6010183
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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