Table of Contents
Experimental Evidence
Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a gain of function (GOF).1
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | High-confidence DLBCL gene |
 |
1 | High-confidence MCL gene |
 |
1 | High-confidence MZL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
MCL
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DLBCL
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Mutation pattern and selective pressure estimates
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NOTCH2 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr1 | 120458147 | G>A | R2400* |
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Expression
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