P2RY8
P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.1 Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL2 and BL.1
History
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1 | high-confidence BL genemuppidiLossSignalingGa132014b? |
 |
1 | high-confidence DLBCL genelohrDiscoveryPrioritizationSomatic2012a? |
 |
2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 6.93 |
| BL | Thomas cohort | 11.00 |
| BL | Panea cohort | NA |
| DLBCL | GAMBL genomes | 6.88 |
| DLBCL | Schmitz cohort | 7.23 |
| DLBCL | Reddy cohort | NA |
| DLBCL | Chapuy cohort | 5.98 |
| FL | GAMBL genomes | 2.31 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | Yes | 58.153 | 189.145 |
| DLBCL | No | Yes | 31.041 | 0.000 |
| FL | No | No | 23.117 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
P2RY8 Expression
References
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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