P2RY8
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
| BL | 1 | high-confidence BL gene |
| DLBCL | 1 | high-confidence DLBCL gene |
| FL | 2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 6.93 |
| BL | Thomas cohort | 11.00 |
| BL | Panea cohort | NA |
| DLBCL | GAMBL genomes | 6.88 |
| DLBCL | Schmitz cohort | 7.23 |
| DLBCL | Reddy cohort | NA |
| DLBCL | Chapuy cohort | 5.98 |
| FL | GAMBL genomes | 2.31 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | Yes | 58.153 | 189.145 |
| DLBCL | No | Yes | 31.041 | 0.000 |
| FL | No | No | 23.117 | 0.000 |
[!NOTE] First described in BL in 2014 by Muppidi JR. First described in DLBCL in 2012 by Lohr JG
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## P2RY8
Expression 
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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