Table of Contents

Relevance tier by entity

Entity Tier Description
BL 3 Mutations are unlikely to be relevant to BL

Warnings

The variants reported in this gene in BL failed QC
Due to minimal support in the original primary data, low expression in BL and very few mutations reported in subsequent studies, this gene is very unlikely to be relevant in BL.

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
BL GAMBL genomes+capture 2.54
BL Thomas cohort NA
BL Panea cohort NA

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 2.0089 0.0000 1.0000
FL 2.2594 9.4897 1.0000
DLBCL 0.0000 0.0000 0.9986

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Expression

Representative Mutations

Rating ★ ☆ ☆ ☆ ☆

Rating ★ ☆ ☆ ☆ ☆

All Mutations

1059 1060 321 512 742

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References

1.
Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

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