PDS5B

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2013-08-15 : Morin : DLBCL 2021-05-05 : Hübschmann : FL

Relevance tier by entity

Entity Tier Description
DLBCL 2 relevance in DLBCL not firmly established1
FL 2 relevance in FL not firmly establishedhubschmannMutationalMechanismsShaping2021b?

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 3.25
DLBCL Schmitz cohort 4.47
DLBCL Reddy cohort 1.80
DLBCL Chapuy cohort 2.14
FL GAMBL genomes 1.62

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 1.009 2.705
DLBCL No No 1.333 6.726
FL No No 0.000 9.065

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

PDS5B Expression

All Mutations

FL2

SP116618 SP116686 SP192804 SP193025 SP193130 SP59360 SP59452

References

1.
Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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