[PDS5B]
Mutation tier
| Entity | Tier | Description |
|---|---|---|
| DLBCL | 2 | relevance in DLBCL not firmly established |
| FL | 2 | relevance in FL not firmly established |
Mutation incidence
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 3.25 |
| DLBCL | Schmitz cohort | 4.47 |
| DLBCL | Reddy cohort | 1.80 |
| DLBCL | Chapuy cohort | 2.14 |
| FL | GAMBL genomes | 1.62 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.009 | 2.705 |
| DLBCL | No | No | 1.333 | 6.726 |
| FL | No | No | 0.000 | 9.065 |
[!NOTE] First described in DLBCL in 2013 by Morin RD. First described in FL in 2021 by Hübschmann D
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Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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