PIK3R1
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in BL not firmly established |
 |
2 | relevance in DLBCL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 3.00 |
| BL | Thomas cohort | 2.50 |
| BL | Panea cohort | 4.00 |
| DLBCL | GAMBL genomes | 1.91 |
| DLBCL | Schmitz cohort | 2.13 |
| DLBCL | Reddy cohort | 2.00 |
| DLBCL | Chapuy cohort | 4.70 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 3.917 | 0.000 |
| DLBCL | No | No | 2.158 | 16.154 |
| FL | No | No | 0.000 | 14.389 |
[!NOTE] First described in BL in 2019 by Panea RI. First described in DLBCL in 2013 by Zhang J
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## PIK3R1
Expression 
## References 1. Zhang J,
Grubor V, Love CL, Banerjee A, Richards KL, Mieczkowski PA, Dunphy C,
Choi W, Au WY, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS,
Bernal-Mizrachi L, Mann KP, Flowers C, Naresh K, Evens A, Gordon LI,
Czader M, Gill JI, Hsi ED, Liu Q, Fan A, Walsh K, Jima D, Smith LL,
Johnson AJ, Byrd JC, Luftig MA, Ni T, Zhu J, Chadburn A, Levy S, Dunson
D, Dave SS. Genetic heterogeneity of diffuse large B-cell lymphoma. 2013
Jan; 2. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A,
Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian
M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B,
Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W,
Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T,
Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy
S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of
Burkitt lymphoma subtypes. Blood. 2019;