PPP4C
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| FL | GAMBL genomes | 2.08 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 2.143 | 25.647 |
| DLBCL | No | No | 6.715 | 0.000 |
| FL | No | No | 43.394 | 0.000 |
## PPP4C Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr16 | 30093814 | G>A | D54N |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## PPP4C
Expression 
## References 1.
Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH,
Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N,
Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H,
Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez
A, Doose G, Haake A, Karsch D, Haas S, Hansmann ML, Hoell JI, Hovestadt
V, Huang B, Hummel M, Jäger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube
D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E,
Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M,
Stilgenbauer S, Stadler PF, Martín-Subero JI, Szczepanowski M, Warsow G,
Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Möller P,
Loeffler M, Eils R, Klapper W, Hoffmann S, Trümper L, ICGC MMML-Seq
consortium, ICGC DE-Mining consortium, BLUEPRINT consortium, Küppers R,
Schlesner M, Siebert R. Mutational mechanisms shaping the coding and
noncoding genome of germinal center derived B-cell lymphomas. Leukemia.
2021 Jul;35(7):2002–2016. PMCID: PMC8257491
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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